Entries by awp-admin

Publications 2015 – Present

220. Anderson DE, Quinn E, Parker E, Allaire B, Muir JW, Rubin CT, Magaziner J, Hannan MT, Bouxsein ML and Kiel DP. Associations of computed tomography-based trunk muscle size and density with balance and falls in older adults. Journal of Gerontology: Medical Sciences, 2015 (in press). 219. Mitchell DM, Tuck P, Ackerman KE, Cano Sokoloff […]

Micro-computed Tomography

Micro-computed tomography (microCT) is an imaging technique that uses x-rays to produce cross-sectional images of an object that can be reconstructed to create a three-dimensional model. It allows for non-destructive quantitative analysis of the density, geometry and microarchitecture of mineralized or high-density material, particularly bone and biomaterials stained with contrast chemicals. The reason the technique […]

Effects of partial weight bearing on musculoskeletal system and inhibition of disuse induced bone loss with novel therapeutics

Mechanical loading is necessary for proper development and maintenance of the musculoskeletal system. Yet, despite the profound effects of reduced mechanical loading on muscle atrophy and skeletal fragility, there has been little investigation into the physiological effects of clinically relevant partial weight-bearing environments, such as bed rest, immobilization, stroke, cerebral palsy, muscular dystrophy, spinal cord […]

Vertebral strength analysis in astronauts after long duration spaceflight on the ISS

QCT images have been used successfully to demonstrate negative effects of spaceflight on bone density and strength of the proximal femur. However, a similar examination of the effects of spaceflight on vertebral strength has not been performed, despite reports of significant trabecular bone loss in the spine in long-duration astronauts. Moreover, no prior studies have […]

Bone biomechanics and skeletal fragility

For several decades we have been investigating the biomechanical mechanisms underlying skeletal fragility in osteoporosis and other bone disorders, and how various interventions improve bone strength and reduce fracture risk. Our work has included studies in animal models, human cadaveric specimens and clinical studies. Our overall goals are to better understand the origins and causes […]

Mechanisms of Diabetic Skeletal Fragility

Patients with type 2 diabetes have 2-3 times greater bone fracture risk than non-diabetics. This increased risk occurs despite these patients having normal to high bone mineral density, which usually is protective against fractures. Thus, causes of type 2 diabetic skeletal fragility are largely unknown and there is limited information on which clinicians can base […]

Microindentation — Reference Point Indentation

As part of our assessment of tissue properties, we perform microindentation using a novel reference point indentation device developed by ActiveLife Scientific. Reference Point Indentation enables assessment of bone material properties without requiring special surface preparation. As such, the measurement can be performed not only on excised bone specimens, but also in vivo. This is […]