Publications 2015 – Present

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318. Black DM, Bauer DC, Vittinghoff E, Lui L-Y, Grauer A, Marin F, Khosla S, de Papp A, Mitlak B, Cauley JA, McCulloch CE, Eastell R, Bouxsein ML for the FNIH Bone Quality Project.  Treatment-related changes in bone mineral density as a surrogate biomarker for fracture risk reduction:  Analysis of individual patient data from multiple randomized clinical trials.  Accepted by Lancet Diabetes & Endocrinology, April 2020.
317. Rezaee T, Bouxsein ML, Karim L.  Increasing fluoride content deteriorates rat bone mechanical properties.  Bone 2020 Apr 19; 115369.  Doi: 10.1016/j.bone.2020.115369.  Online ahead of print.  PubMed PMID: 32320892.
316. Keaveny TM, Clarke BL, Cosman F, Orwoll ES, Siris ES, Khosla S, Bouxsein ML. Biomechanical computed tomography analysis (BCT) for clinical assessment of osteoporosis.  Osteoporosis Int.  Published Online 4/26/20.
315. Bouxsein ML, Zysset P, Gluer CC, McClung M, Biver E, Pierroz DD, Ferrari SL. Perspectives on the non-invasive evaluation of femoral strength in the assessment of hip fracture risk. Osteoporos Int. 2020;31(3):393-408. doi: 10.1007/s00198-019-05195-0. PubMed PMID: 31900541.
314. Burkhart K, Allaire B, Anderson DE, Lee D, Keaveny TM, Bouxsein ML. Effects of long-duration spaceflight on vertebral strength and risk of spine fracture.  J Bone Min Res 2020;35(2):269-276. doi: 10.1002/jbmr.3881. PubMed PMID: 31670861.
313. Howe JG, Hill RS, Stroncek JD, Shaul JL, Favell D, Cheng RR, Engelke K, Genant HK, Lee DC, Keaveny TM, Bouxsein ML, Huber B. Treatment of bone loss in proximal femurs of postmenopausal osteoporotic women with AGN1 local osteo-enhancement procedure (LOEP) increases hip bone mineral density and hip strength: a long-term prospective cohort study. Osteoporos Int. 2020;31(5):921-929. doi: 10.1007/s00198-019-05230-0. PubMed PMID: 31802158.
312. Kaiser J, Allaire B, Fein PM, Lu D, Adams A, Kiel DP, Jarraya M, Guermazi A, Demissie S, Samelson EJ, Bouxsein ML, Morgan EF. Heterogeneity and Spatial Distribution of Intravertebral Trabecular Bone Mineral Density in the Lumbar Spine is Associated with Prevalent Vertebral Fracture. J Bone Miner Res. 2020;35(4):641-648. doi: 10.1002/jbmr.3946. PubMed PMID: 31886907; PMCID: PMC7145746.
311. Fazeli PK, Faje AT, Meenaghan E, Russell ST, Resulaj M, Lee H, Rosen CJ, Bouxsein ML, Klibanski A. IGF-1 is associated with estimated bone strength in anorexia nervosa. Osteoporos Int. 2020;31(2):259-265. doi: 10.1007/s00198-019-05193-2. PubMed PMID: 31656971; PMCID: PMC7012750.
310. Ackerman KE, Singhal V, Slattery M, Eddy KT, Bouxsein ML, Lee H, Klibanski A, Misra M. Effects of Estrogen Replacement on Bone Geometry and Microarchitecture in Adolescent and Young Adult Oligoamenorrheic Athletes: A Randomized Trial. J Bone Miner Res. 2020;35(2):248-260. doi: 10.1002/jbmr.3887. PubMed PMID: 31603998; PMCID: PMC7064307.
309. Mitchell DM, Caksa S, Joseph T, Bouxsein ML, Misra M. Elevated HbA1c is associated with altered cortical and trabecular microarchitecture in girls with type 1 diabetes. J Clin Endocrinol Metab. 2020;105(4):e1648-31656. doi: 10.1210/clinem/dgz221. PubMed PMID: 31761940; PMCID: PMC7064304.
308. Noda H, Guo J, Khatri A, Dean T, Reyes M, Armanini M, Brooks DJ, Martins JS, Schipani E, Bouxsein ML, Demay MB, Potts JT, Jr., Juppner H, Gardella TJ. An Inverse Agonist Ligand of the PTH Receptor Partially Rescues Skeletal Defects in a Mouse Model of Jansen’s Metaphyseal Chondrodysplasia. J Bone Miner Res. 2020;35(3):540-549. doi: 10.1002/jbmr.3913. PubMed PMID: 31693237.
307. Draghici AE, Taylor JA, Bouxsein ML, Shefelbine SJ. Effects of FES-Rowing Exercise on the Time-Dependent Changes in Bone Microarchitecture After Spinal Cord Injury: A Cross-Sectional Investigation. JBMR Plus. 2019;3(9):e10200. doi: 10.1002/jbm4.10200. PubMed PMID: 31667456; PMCID: PMC6808228.
306. Mortreux M, Riveros D, Bouxsein ML, Rutkove SB. A Moderate Daily Dose of Resveratrol Mitigates Muscle Deconditioning in a Martian Gravity Analog. Front Physiol. 2019;10:899. doi: 10.3389/fphys.2019.00899. PubMed PMID: 31379604; PMCID: PMC6656861.
305. Nishimori S, O’Meara MJ, Castro CD, Noda H, Cetinbas M, da Silva Martins J, Ayturk U, Brooks DJ, Bruce M, Nagata M, Ono W, Janton CJ, Bouxsein ML, Foretz M, Berdeaux R, Sadreyev RI, Gardella TJ, Juppner H, Kronenberg HM, Wein MN. Salt-inducible kinases dictate parathyroid hormone 1 receptor action in bone development and remodeling. J Clin Invest. 2019;129(12):5187-5203. doi: 10.1172/JCI130126. PubMed PMID: 31430259; PMCID: PMC6877304.
304. Mortreux M, Ko FC, Riveros D, Bouxsein ML, Rutkove SB. Longitudinal time course of muscle impairments during partial weight-bearing in rats. NPJ Microgravity. 2019;5:20. doi: 10.1038/s41526-019-0080-5. PubMed PMID: 31453318; PMCID: PMC6706399.
303. Dawson-Hughes B, Bouxsein M, Shea K. Bone material strength in normoglycemic and hyperglycemic black and white older adults. Osteoporos Int. 2019;30(12):2429-35. doi: 10.1007/s00198-019-05140-1. PubMed PMID: 31463589; PMCID: PMC6879849.
302. Nishimori S, O’Meara MJ, Castro CD, Noda H, Cetinbas M, da Silva Martins J, Ayturk U, Brooks DJ, Bruce M, Nagata M, Ono W, Janton CJ, Bouxsein ML, Foretz M, Berdeaux R, Sadreyev RI, Gardella TJ, Jüppner H, Kronenberg HM, Wein MN. Salt-inducible kinases dictate parathyroid hormone 1 receptor action in bone development and remodeling. J Clin Invest. 2019 Dec 2;129(12):5187-5203. doi: 10.1172/JCI130126.  PubMed PMID: 31430259; PMCID: PMC6877304.
301. Kim H, Wrann CD, Jedrychowski M, Vidoni S, Kitase Y, Nagano K, Zhou C, Chou J, Parkman VA, Novick SJ, Strutzenberg TS, Pascal BD, Le PT, Brooks DJ, Roche AM, Gerber KK, Mattheis L, Chen W, Tu H, Bouxsein ML, Griffin PR, Baron R, Rosen CJ, Bonewald LF, Spiegelman BM. Irisin Mediates Effects on Bone and Fat via alphaV Integrin Receptors. Cell. 2019;178(2):507-8. doi: 10.1016/j.cell.2019.06.028. PubMed PMID: 31299203; PMCID: PMC6707723.
300. Popp KL, Turkington V, Hughes JM, Xu C, Unnikrishnan G, Reifman J, Bouxsein ML. Skeletal loading score is associated with bone microarchitecture in young adults. Bone. 2019;127:360-6. doi: 10.1016/j.bone.2019.06.001. PubMed PMID: 31265923.
299. Hughes JM, Foulis SA, Taylor KM, Guerriere KI, Walker LA, Hand AF, Popp KL, Gaffney-Stomberg E, Heaton KJ, Sharp MA, Grier TL, Hauret KG, Jones BH, Bouxsein ML, McClung JP, Matheny RW, Jr., Proctor SP. A prospective field study of U.S. Army trainees to identify the physiological bases and key factors influencing musculoskeletal injuries: a study protocol. BMC Musculoskelet Disord. 2019;20(1):282. doi: 10.1186/s12891-019-2634-9. PubMed PMID: 31185965; PMCID: PMC6560880
298. Tsai JN, Nishiyama KK, Lin D, Yuan A, Lee H, Bouxsein ML, Leder BZ. Effects of Denosumab and Teriparatide Transitions on Bone Microarchitecture and Estimated Strength: the DATA-Switch HR-pQCT Study. J Bone Miner Res. 2019;34(5):976. doi: 10.1002/jbmr.3707. PubMed PMID: 31132317
297. Lotinun S, Ishihara Y, Nagano K, Kiviranta R, Carpentier VT, Neff L, Parkman V, Ide N, Hu D, Dann P, Brooks D, Bouxsein ML, Wysolmerski J, Gori F, Baron R. Cathepsin K-deficient osteocytes prevent lactation-induced bone loss and parathyroid hormone suppression. J Clin Invest. 2019;129:3058-3071. doi: 10.1172/JCI122936. PubMed PMID: 31112135; PMCID: PMC6668688.
296. Besschetnova T, Brooks DJ, Hu D, Nagano K, Nustad J, Ominsky M, Mitlak B, Hattersley G, Bouxsein ML, Baron R, Lanske B. Abaloparatide improves cortical geometry and trabecular microarchitecture and increases vertebral and femoral neck strength in a rat model of male osteoporosis. Bone. 2019;124:148-57. doi: 10.1016/j.bone.2019.04.025. PubMed PMID: 31051317.
295. Sundaramurthy A, Xu C, Hughes JM, Gaffney-Stomberg E, Guerriere KI, Popp KL, Bouxsein ML, Reifman J, Unnikrishnan G. Regional Changes in Density and Microarchitecture in the Ultradistal Tibia of Female Recruits After U.S. Army Basic Combat Training. Calcif Tissue Int. 2019;105(1):68-76. doi: 10.1007/s00223-019-00548-7. PubMed PMID: 31011765
294. Mortreux M, Riveros D, Bouxsein ML, Rutkove SB. Mimicking a Space Mission to Mars Using Hindlimb Unloading and Partial Weight Bearing in Rats. J Vis Exp. 2019(146). doi: 10.3791/59327. PubMed PMID: 31009001
293. Caksa S, Yuan A, Rudolph SE, Yu EW, Popp KL, Bouxsein ML. Influence of soft tissue on bone density and microarchitecture measurements by high-resolution peripheral quantitative computed tomography. Bone. 2019;124:47-52. doi: 10.1016/j.bone.2019.04.008. PubMed PMID: 30998999
292. Chandler H, Brooks DJ, Hattersley G, Bouxsein ML, Lanske B. Abaloparatide increases bone mineral density and bone strength in ovariectomized rabbits with glucocorticoid-induced osteopenia. Osteoporos Int. 2019;30(8):1607-16. doi: 10.1007/s00198-019-04999-4. PubMed PMID: 31053927; PMCID: PMC6663928.
291. Burkhart K, Allaire B, Bouxsein ML. Negative Effects of Long-duration Spaceflight on Paraspinal Muscle Morphology. Spine (Phila Pa 1976). 2019;44(12):879-86. doi: 10.1097/BRS.0000000000002959. PubMed PMID: 30624302
290. Stroncek JD, Shaul JL, Favell D, Hill RS, Huber BM, Howe JG, Bouxsein ML. In vitro injection of osteoporotic cadaveric femurs with a triphasic calcium-based implant confers immediate biomechanical integrity. J Orthop Res. 2019;37(4):908-15. doi: 10.1002/jor.24239. PubMed PMID: 30793358; PMCID: PMC6593990.
289. Ebeling PR, Akesson K, Bauer DC, Buchbinder R, Eastell R, Fink HA, Giangregorio L, Guanabens N, Kado D, Kallmes D, Katzman W, Rodriguez A, Wermers R, Wilson HA, Bouxsein ML. The Efficacy and Safety of Vertebral Augmentation: A Second ASBMR Task Force Report. J Bone Miner Res. 2019;34(1):3-21. doi: 10.1002/jbmr.3653. PubMed PMID: 30677181.
288. Popp KL, Xu C, Yuan A, Hughes JM, Unnikrishnan G, Reifman J, Bouxsein ML. Trabecular microstructure is influenced by race and sex in Black and White young adults. Osteoporos Int. 2019;30(1):201-9. doi: 10.1007/s00198-018-4729-9. PubMed PMID: 30397770.
287. Maridas DE, Rendina-Ruedy E, Helderman RC, DeMambro VE, Brooks D, Guntur AR, Lanske B, Bouxsein ML, Rosen CJ. Progenitor recruitment and adipogenic lipolysis contribute to the anabolic actions of parathyroid hormone on the skeleton. FASEB J. 2019;33(2):2885-98. doi: 10.1096/fj.201800948RR. PubMed PMID: 30354669; PMCID: PMC6338651.
286. Hughes JM, McKinnon CJ, Taylor KM, Kardouni JR, Bulathsinhala L, Guerriere KI, Popp KL, Bouxsein ML, Proctor SP, Matheny RW, Jr. Nonsteroidal anti-inflammatory drug prescriptions are associated with increased stress fracture diagnosis in the US Army population. J Bone Miner Res. 2019;34(3):429-36. doi: 10.1002/jbmr.3616. PubMed PMID: 30352135; PMCID: PMC6936225.
285. Allaire BT, Lu D, Johannesdottir F, Kopperdahl D, Keaveny TM, Jarraya M, Guermazi A, Bredella MA, Samelson EJ, Kiel DP, Anderson DE, Demissie S, Bouxsein ML. Prediction of incident vertebral fracture using CT-based finite element analysis. Osteoporos Int. 2019;30(2):323-31. doi: 10.1007/s00198-018-4716-1. PubMed PMID: 30306225; PMCID: PMC6450770.
284. Ackerman KE, Singhal V, Baskaran C, Slattery M, Campoverde Reyes KJ, Toth A, Eddy KT, Bouxsein ML, Lee H, Klibanski A, Misra M. Oestrogen replacement improves bone mineral density in oligo-amenorrhoeic athletes: a randomised clinical trial. Br J Sports Med. 2019;53(4):229-36. doi: 10.1136/bjsports-2018-099723. PubMed PMID: 30301734; PMCID: PMC66686188.
283. Popp KL, Caksa S, Martinez-Betancourt A, Yuan A, Tsai J, Yu EW, Bouxsein ML. Cortical Bone Material Strength Index and Bone Microarchitecture in Postmenopausal Women With Atypical Femoral Fractures. J Bone Miner Res. 2019;34(1):75-82. doi: 10.1002/jbmr.3590. PubMed PMID: 30281863.
282. Lorbergs AL, Allaire BT, Yang L, Kiel DP, Cupples LA, Jarraya M, Guermazi A, Travison TG, Bouxsein ML, Anderson DE, Samelson EJ. A Longitudinal Study of Trunk Muscle Properties and Severity of Thoracic Kyphosis in Women and Men: The Framingham Study. J Gerontol A Biol Sci Med Sci. 2019;74(3):420-7. doi: 10.1093/gerona/gly056. PubMed PMID: 29688268; PMCID: PMC6376109.
281. Samelson EJ, Broe KE, Xu H, Yang L, Boyd S, Biver E, Szulc P, Adachi J, Amin S, Atkinson E, Berger C, Burt L, Chapurlat R, Chevalley T, Ferrari S, Goltzman D, Hanley DA, Hannan MT, Khosla S, Liu CT, Lorentzon M, Mellstrom D, Merle B, Nethander M, Rizzoli R, Sornay-Rendu E, Van Rietbergen B, Sundh D, Wong AKO, Ohlsson C, Demissie S, Kiel DP, Bouxsein ML. Cortical and trabecular bone microarchitecture as an independent predictor of incident fracture risk in older women and men in the Bone Microarchitecture International Consortium (BoMIC): a prospective study. Lancet Diabetes Endocrinol. 2019;7(1):34-43. doi: 10.1016/S2213-8587(18)30308-5. PubMed PMID: 30503163; PMCID: PMC6354581.
280. Bouxsein ML, Eastell R, Lui LY, Wu LA, de Papp AE, Grauer A, Marin F, Cauley JA, Bauer DC, Black DM, Project FBQ. Change in Bone Density and Reduction in Fracture Risk: A Meta-Regression of Published Trials. J Bone Miner Res. 2019;34(4):632-42. doi: 10.1002/jbmr.3641. PubMed PMID: 30674078
279. Fulzele K, Dedic C, Lai F, Bouxsein M, Lotinun S, Baron R, Divieti Pajevic P. Loss of Gsalpha in osteocytes leads to osteopenia due to sclerostin induced suppression of osteoblast activity. Bone. 2018;117:138-48. doi: 10.1016/j.bone.2018.09.021. PubMed PMID: 30266511.
278. Whittier DE, Manske SL, Kiel DP, Bouxsein ML, Boyd S. Harmonizing finite element modelling for non-invasive strength estimation by HR-pQCT.  J Biomech. 2018;80:63-71. doi: 10.1016/j.jbiomech.2018.08.030. PubMed PMID: 30201250; PMCID: PMC6188787.
277. Lindeman KG, Greenblatt LB, Rourke C, Bouxsein ML, Finkelstein JS, Yu EW. Longitudinal 5-year evaluation of bone density and microarchitecture after Roux-en-Y gastric bypass surgery. J Clin Endocrinol Metab. 2018;103(11):4104-4112. doi: 10.1210/jc.2018-01496. PubMed PMID: 30219833; PMCID: PMC6194805.
276. van Dongen LH, Kiel DP, Soedamah-Muthu SS, Bouxsein ML, Hannan MT, Sahni S. Higher Dairy Food Intake Is Associated With Higher Spine Quantitative Computed Tomography (QCT) Bone Measures in the Framingham Study for Men But Not Women. J Bone Miner Res. 2018;33(7):1283-90. doi: 10.1002/jbmr.3414. PubMed PMID: 29480959.
275. Devlin MJ, Robbins A, Cosman MN, Moursi CA, Cloutier AM, Louis L, Van Vliet M, Conlon C, Bouxsein ML. Differential effects of high fat diet and diet-induced obesity on skeletal acquisition in female C57BL/6J vs. FVB/NJ Mice. Bone Rep. 2018;8:204-14. doi: 10.1016/j.bonr.2018.04.003. PubMed PMID: 29955639; PMCID: PMC6020275.
274. Karim L, Moulton J, Van Vliet M, Velie K, Robbins A, Malekipour F, Abdeen A, Ayres D, Bouxsein ML. Bone microarchitecture, biomechanical properties, and advanced glycation end-products in the proximal femur of adults with type 2 diabetes. Bone. 2018;114:32-9. doi: 10.1016/j.bone.2018.05.030. PubMed PMID: 29857063.
273. Liu CT, Sahni S, Xu H, McLean RR, Broe KE, Hannan MT, Boyd SK, Bouxsein ML, Kiel DP, Samelson EJ. Long-Term and Recent Weight Change are Associated with Reduced Peripheral Bone Density, Deficits in Bone Microarchitecture, and Decreased Bone Strength: The Framingham Osteoporosis Study. J Bone Miner Res. 2018;33(10):1851-1858. doi: 10.1002/jbmr.3472. PubMed PMID: 29813182; PMCID: PMC6368222.
272. Black DM, Abrahamsen B, Bouxsein ML, Einhorn T, Napoli N. Atypical Femur Fractures – Review of epidemiology, relationship to bisphosphonates, prevention and clinical management. Endocr Rev. 2018. doi: 10.1210/er.2018-00001. PubMed PMID: 30169557
271. Unnikrishnan G, Xu C, Popp KL, Hughes JM, Yuan A, Guerriere KI, Caksa S, Ackerman KE, Bouxsein ML, Reifman J. Regional variation of bone density, microarchitectural parameters, and elastic moduli in the ultradistal tibia of young black and white men and women. Bone. 2018;112:194-201. doi: 10.1016/j.bone.2018.05.004. PubMed PMID: 29730277.
270. Hughes JM, Gaffney-Stomberg E, Guerriere KI, Taylor KM, Popp KL, Xu C, Unnikrishnan G, Staab JS, Matheny RW, Jr., McClung JP, Reifman J, Bouxsein ML. Changes in tibial bone microarchitecture in female recruits in response to 8weeks of U.S. Army Basic Combat Training. Bone. 2018;113:9-16. doi: 10.1016/j.bone.2018.04.021. PubMed PMID: 29709620.
269. Kuehn F, Adiliaghdam F, Hamarneh SR, Vasan R, Liu E, Liu Y, Ramirez JM, Hoda RS, Munoz AR, Ko FC, Armanini M, Brooks DJ, Bouxsein ML, Demay MB, Hodin RA. Loss of intenstinal alkaline phosphatase leads to distinct chronic changes in bone phenotype. J Surg Res. 2018;232:325-331. doi: 10.1016/j.jss.2018.06.061.  PubMed PMID: 30463736.
268. Kaiser J, Allaire B, Fein PM, Lu D, Jarraya M, Guermazi A, Demissie S, Samelson EJ, Bouxsein ML, Morgan EF. Correspondence between bone mineral density and intervertebral disc degeneration across age and sex.  Arch Osteoporos. 2018; 13(1):123.  doi: 10.1007/511 657-018-0538-1.  PubMed PMID: 30421154; PMCID: PMC6291246.
267. Jarraya M, Guermazi A, Lorbergs AL, Brochin E, Kiel DP, Bouxsein ML, Cupples LA, Samelson EJ. A longitudinal study of disc height narrowing and facet joint osteoarthritis at the thoracic and lumbar spine, evaluated by computed tomography: the Framingham Study. Spine J. 2018;18(11):2065-2073. doi: 10.1016/j.spinee.2018.04.010. PubMed PMID: 29679729; PMCID: PMC6195485.
266. Adams AL, Fischer H, Kopperdahl DL, Lee DC, Black DM, Bouxsein ML, Fatemi S, Khosla S, Orwoll ES, Siris ES, Keaveny TM. Osteoporosis and Hip Fracture Risk From Routine Computed Tomography Scans: The Fracture, Osteoporosis, and CT Utilization Study (FOCUS). J Bone Miner Res. 2018;33(7):1291-301. doi: 10.1002/jbmr.3423. PubMed PMID: 29665068.
265. Ko, FC, Li J, Brooks DJ, Rutkove SB, Bouxsein ML. Structural and functional properties of bone are compromised in amyotrophic lateral sclerosis mice. Amyotroph Lateral Scler Frontotemporal Degener. 2018;a9(5-6):457-462. doi: 10.1080/21678421.2018.1452946. PubMed PMID: 29569488; PMCID: PMC6141014.
264. Mortreux M, Nagy JA, Ko FC, Bouxsein ML, Rutkove SB. A novel partial gravity ground-based analogue for rats via quadrupedal unloading. J Appl Physiol (1985). 2018;125(1):175-182. doi: 10.1152/japplphysiol.01083.2017. PubMed PMID: 29565773.
263. Johannesdottir F, Allaire B, Anderson DE, Samelson EJ, Kiel DP, Bouxsein ML. Population-based study of age- and sex-related differences in muscle density and size in thoracic and lumbar spine: the Framingham study. Osteoporos Int. 2018;29(7):1569-1580. doi: 10.1007/s00198-018-4490-0. PubMed PMID: 29564476; PMCID: PMC6035769.
262. Johannesdottir F, Allaire B, Bouxsein ML. Fracture Prediction by Computed Tomography and Finite Element Analysis: Current and Future Perspectives. Curr Osteoporos Rep. 2018;16(4):411-22. doi: 10.1007/s11914-018-0450-z. PubMed PMID: 29846870.
261. Christov M, Clark AR, Corbin B, Hakroush S, Rhee EP, Saito H, Brooks DJ, Hesse E, Bouxsein M, Galjart N, Jung J-Y, Mundel P, Jüppner H, Weins A, Greka A.  Inducible podocyte-specific deletion of CTCF drives progressive kidney disease and bone abnormalities. JCI Insight. 2018;3(4). doi: 10.1172/jci.insight.95091. PubMed PMID: 29467330; PMCID: PMC5916242.
260. Bauer DC, Black DM, Bouxsein ML, Lui LY, Cauley JA, de Papp AE, Grauer A, Khosla S, McCulloch CE, Eastell R, Foundation for the National Institutes of Health Bone Quality P. Treatment-Related Changes in Bone Turnover and Fracture Risk Reduction in Clinical Trials of Anti-Resorptive Drugs: A Meta-Regression. J Bone Miner Res. 2018;33(4):634-42. doi: 10.1002/jbmr.3355. PubMed PMID: 29318649.
259. Samelson EJ, Demissie S, Cupples LA, Zhang X, Xu H, Liu CT, Boyd SK, McLean RR, Broe KE, Kiel DP, Bouxsein ML. Diabetes and Deficits in Cortical Bone Density, Microarchitecture, and Bone Size: Framingham HR-pQCT Study. J Bone Miner Res 2018;33(1):54-62. doi: 10.1002/jbmr.3240. PubMed PMID: 28929525; PMCID: PMC5771832.
258. Mitchell DM, Caksa S, Yuan A, Bouxsein ML, Misra M, Burnett-Bowie SM. Trabecular Bone Morphology Correlates with Skeletal Maturity and Body Composition in Healthy Adolescent Girls. J Clin Endocrinol Metab. 2018;103(1):336-45. doi: 10.1210/jc.2017-01785. PubMed PMID: 29121215; PMCID: PMC5761494.
257. Rozental TD, Johannesdottir F, Kempland KC, Bouxsein ML. Characterization of trabecular bone microstructure in premenopausal women with distal radius fractures. Osteoporos Int. 2018;29(2):409-19. doi: 10.1007/s00198-017-4293-8. PubMed PMID: 29101409.
256. Rozental TD, Walley KC, Demissie S, Caksa S, Martinez-Betancourt A, Parker AM, Tsai JN, Yu EW, Bouxsein ML. Bone material strength index as measured by impact microindentation in postmenopausal women with distal radius and hip fractures. J Bone Miner Res. 2018;33(4):621-6. doi: 10.1002/jbmr.3338. PubMed PMID: 29115684.
255. Anderson DE, Mannen EM, Tromp R, Wong BM, Sis HL, Cadel ES, Friis EA, Bouxsein ML. The rib cage reduces intervertebral disc pressures in cadaveric thoracic spines by sharing loading under applied dynamic moments. J Biomech. 2018;70:262-266. doi: 10.1016/j.jbiomech..10.005. PubMed PMID: 29106896.
254. Burkhart KA, Bruno AG, Bouxsein ML, Bean JF, Anderson DE. Estimating apparent maximum muscle stress of trunk extensor muscles in older adults using subject-specific musculoskeletal models. J Orthop Res. 2018;36(1):498-505. doi: 10.1002/jor.23630. PubMed PMID: 28597988; PMCID: PMC5723244
253. Tsai JN, Nishiyama KK, Lin D, Yuan A, Lee H, Bouxsein ML, Leder BZ. Effects of Denosumab and Teriparatide Transitions on Bone Microarchitecture and Estimated Strength: the DATA-Switch HR-pQCT study. J Bone Miner Res. 2017;32(10):2001-9. doi: 10.1002/jbmr.3198. PubMed PMID: 28608571.
252. Karasik D, Demissie S, Lu D, Broe KE, Boyd SK, Liu CT, Hsu YH, Bouxsein ML, Kiel DP. Bone Strength Estimated by Micro-Finite Element Analysis (microFEA) Is Heritable and Shares Genetic Predisposition With Areal BMD: The Framingham Study. J Bone Miner Res. 2017;32(11):2151-6. doi: 10.1002/jbmr.3200. PubMed PMID: 28722129; PMCID: PMC5685872.
251. Ko FC, van Vliet M, Ellman R, Grasso D, Brooks DJ, Spatz JM, Conlon C, Aguirre J, Wronski T, Bouxsein ML. Treatment with a soluble bone morphogenetic protein Type 1A receptor (BMPR1A) fusion protein increases bone mass and bone formation in mice subjected to hindlimb unloading.  JBMRPlus 2017;1(2):66-72. Epub 9 Oct 2017. doi: 10.1002/jbm4.10012.
250. Johannesdottir F, Thrall E, Muller J, Keaveny TM, Kopperdahl DL, Bouxsein ML. Comparison of non-invasive assessments of strength of the proximal femur. Bone. 2017;105:93-102. doi: 10.1016/j.bone.2017.07.023. PubMed PMID: 28739416.
249. Silva PP, Ghazanfari Amlashi F, Yu EW, Pulaski-Liebert KJ, Gerweck A, Fazeli P, Lawson EA, Nachtigall LB, Biller BMK, Miller KK, Klibanski A, Bouxsein M, Tritos NA. Bone Microarchitecture and Estimated Bone Strength in Men with Active Acromegaly. Eur J Endocrinol. Eur J Endocrinol. 2017;177(5):409-20. doi: 10.1530/EJE-17-0468. PubMed PMID: 28780520.
248. Lorbergs AL, Murabito JM, Jarraya M, Guermazi A, Allaire BT, Yang L, Kiel DP, Cupples LA, Bouxsein ML, Travison TG, Samelson EJ. Thoracic Kyphosis and Physical Function: The Framingham Study. J Am Geriatr Soc. 2017;65(10):2257-64. doi: 10.1111/jgs.15038. PubMed PMID: 28832926; PMCID: PMC5641235
247. Le PT, Bishop KA, Maridas DE, Motyl KJ, Brooks DJ, Nagano K, Baron R, Bouxsein ML, Rosen CJ. Spontaneous mutation of Dock7 results in lower trabecular bone mass and impaired periosteal expansion in aged female Misty mice. Bone. 2017;105:103-14. doi: 10.1016/j.bone.2017.08.006. PubMed PMID: 28821457
246. Popp KL, Hughes JM, Martinez-Betancourt A, Scott M, Turkington V, Caksa S, Guerriere KI, Ackerman KE, Xu C, Unnikrishnan G, Reifman J, Bouxsein ML. Bone mass, microarchitecture and strength are influenced by race/ethnicity in young adult men and women. Bone. 2017;103:200-8. doi: 10.1016/j.bone.2017.07.014. PubMed PMID: 28712877.
245. Bruno AG, Burkhart K, Allaire B, Anderson DE, Bouxsein ML. Spinal Loading Patterns From Biomechanical Modeling Explain the High Incidence of Vertebral Fractures in the Thoracolumbar Region. J Bone Miner Res. 2017;32(6):1282-90. doi: 10.1002/jbmr.3113. PubMed PMID: 28244135; PMCID: PMC5466490.
244. Liu CT, Broe KE, Zhou Y, Boyd SK, Cupples LA, Hannan MT, Lim E, McLean RR, Samelson EJ, Bouxsein ML, Kiel DP. Visceral Adipose Tissue Is Associated With Bone Microarchitecture in the Framingham Osteoporosis Study. J Bone Miner Res. 2017;32(1):143-50. doi: 10.1002/jbmr.2931. PubMed PMID: 27487454; PMCID: PMC5316419
243. Bulathsinhala L, Hughes JM, McKinnon CJ, Kardouni JR, Guerriere KI, Popp KL, Matheny RW, Jr., Bouxsein ML. Risk of Stress Fracture Varies by Race/Ethnic Origin in a Cohort Study of 1.3 Million U.S. Army Soldiers. J Bone Miner Res. 2017; 32(7):1546-53, doi: 10.1002/jbmr.3131. PubMed PMID: 28300324.
242. Jin YR, Stohn JP, Wang Q, Nagano K, Baron R, Bouxsein ML, Rosen CJ, Adarichev VA, Lindner V. Inhibition of osteoclast differentiation and collagen antibody-induced arthritis by CTHRC1. Bone. 2017;97:153-67. doi: 10.1016/j.bone.2017.01.022. PubMed PMID: 28115279.
241. Spatz JM, Ellman R, Cloutier AM, Louis L, van Vliet M, Dwyer D, Stolina M, Ke HZ, Bouxsein ML. Sclerostin antibody inhibits skeletal deterioration in mice exposed to partial weight-bearing. Life Sci Space Res (Amst). 2017;12:32-8. doi: 10.1016/j.lssr.2017.01.001. PubMed PMID: 28212706.
240. Bruno AG, Mokhtarzadeh H, Allaire BT, Velie KR, De Paolis Kaluza MC, Anderson DE, Bouxsein ML. Incorporation of CT-based measurements of trunk anatomy into subject-specific musculoskeletal models of the spine influences vertebral loading predictions. J Orthop Res. 2017. doi: 10.1002/jor.23524. PubMed PMID: 28092118.
239. Karasik D, Demissie S, Zhou Y, Lu D, Broe KE, Bouxsein ML, Cupples LA, Kiel DP. Heritability and Genetic Correlations for Bone Microarchitecture: The Framingham Study Families. J Bone Miner Res. 2017;32(1):106-14. doi: 10.1002/jbmr.2915. PubMed PMID: 27419666.
238. Allaire BT, DePaolis Kaluza MC, Bruno AG, Samelson EJ, Kiel DP, Anderson DE, Bouxsein ML. Evaluation of a new approach to compute intervertebral disc height measurements from lateral radiographic views of the spine. Eur Spine J. 2017;26(1):167-72. doi: 10.1007/s00586-016-4817-5. PubMed PMID: 27757680.
237. Maddaloni E, D’Eon S, Hastings S, Tinsley LJ, Napoli N, Khamaisi M, Bouxsein ML, Fouda SM, Keenan HA. Bone health in subjects with type 1 diabetes for more than 50 years. Acta Diabetol. 2017;54(5):479-88. doi: 10.1007/s00592-017-0973-2. PubMed PMID: 28236093; PMCID: PMC5406751.
236. Bonaretti S, Vilayphiou N, Chan CM, Yu A, Nishiyama K, Liu D, Boutroy S, Ghasem-Zadeh A, Boyd SK, Chapurlat R, McKay H, Shane E, Bouxsein ML, Black DM, Majumdar S, Orwoll ES, Lang TF, Khosla S, Burghardt AJ. Operator variability in scan positioning is a major component of HR-pQCT precision error and is reduced by standardized training. Osteoporos Int. 2017;28(1):245-57. doi: 10.1007/s00198-016-3705-5. PubMed PMID: 27475931
235. Liu CT, Broe KE, Zhou Y, Boyd SK, Cupples LA, Hannan MT, Lim E, McLean RR, Samelson EJ, Bouxsein ML, Kiel DP. Visceral Adipose Tissue Is Associated With Bone Microarchitecture in the Framingham Osteoporosis Study. J Bone Miner Res. 2017;32(1):143-50. doi: 10.1002/jbmr.2931. PubMed PMID: 27487454
234. Putman MS, Yu EW, Lin D, Darakananda K, Finkelstein JS, Bouxsein ML. Differences in Trabecular Microstructure between Black and White Women Assessed by Individual Trabecular Segmentation Analysis of HR-pQCT Images. J Bone Miner Res. 2017;32(5):1100-8. doi: 10.1002/jbmr.3060. PubMed PMID: 27958659; PMCID: PMC5413370.
233. Ko FC, Karim L, Brooks DJ, Bouxsein ML, Demay MB. Bisphosphonate Withdrawal: Effects on Bone Formation and Bone Resorption in Maturing Male Mice. J Bone Miner Res. 2017;32(4):814-20. doi: 10.1002/jbmr.3052. PubMed PMID: 27925290.
232. Misra M, Ackerman KE, Bredella MA, Stanford FC, Faje AT, Nordberg A, Derrico NP, Bouxsein ML. Racial Differences in Bone Microarchitecture and Estimated Strength at the Distal Radius and Distal Tibia in Older Adolescent Girls: a Cross-Sectional Study. J Racial Ethn Health Disparities. 2017;4(4):587-98. doi: 10.1007/s40615-016-0262-8. PubMed PMID: 27387309; PMCID: PMC5222729.
231. Yau MS, Demissie S, Zhou Y, Anderson DE, Lorbergs AL, Kiel DP, Allaire BT, Yang L, Cupples LA, Travison TG, Bouxsein ML, Karasik D, Samelson EJ. Heritability of Thoracic Spine Curvature and Genetic Correlations With Other Spine Traits: The Framingham Study. J Bone Miner Res. 2016;31(12):2077-84. doi: 10.1002/jbmr.2925. PubMed PMID: 27455046.
230. Wein MN, Liang Y, Goransson O, Sundberg TB, Wang J, Williams EA, O’Meara MJ, Govea N, Beqo B, Nishimori S, Nagano K, Brooks DJ, Martins JS, Corbin B, Anselmo A, Sadreyev R, Wu JY, Sakamoto K, Foretz M, Xavier RJ, Baron R, Bouxsein ML, Gardella TJ, Divieti-Pajevic P, Gray NS, Kronenberg HM. SIKs control osteocyte responses to parathyroid hormone. Nat Commun. 2016;7:13176. doi: 10.1038/ncomms13176. PubMed PMID: 27759007; PMCID: PMC5075806.
229. Yu EW, Carmody JS, Brooks DJ, LaJoie S, Kaplan LM, Bouxsein ML. Cortical and trabecular deterioration in mouse models of Roux-en-Y gastric bypass. Bone. 2016;85:23-8. doi: 10.1016/j.bone.2016.01.017. PubMed PMID: 26806052; PMCID: PMC4792678.
228. Diez-Perez A, Bouxsein ML, Eriksen EF, Khosla S, Nyman JS, Papapoulos S, Tang SY. Technical note: Recommendations for a standard procedure to assess cortical bone at the tissue-level in vivo using impact microindentation. Bone Rep. 2016;5:181-5. doi: 10.1016/j.bonr.2016.07.004. PubMed PMID: 27975078; PMCID: PMC5152622.
227. Shanbhogue VV, Finkelstein JS, Bouxsein ML, Yu EW. Association Between Insulin Resistance and Bone Structure in Nondiabetic Postmenopausal Women. J Clin Endocrinol Metab. 2016;101(8):3114-22. doi: 10.1210/jc.2016-1726. PubMed PMID: 27243136; PMCID: PMC4971339.
226. Nielson CM, Liu CT, Smith AV, Ackert-Bicknell CL, Reppe S, Jakobsdottir J, Wassel C, Register TC, Oei L, Alonso N, Oei EH, Parimi N, Samelson EJ, Nalls MA, Zmuda J, Lang T, Bouxsein M, Latourelle J, Claussnitzer M, Siggeirsdottir K, Srikanth P, Lorentzen E, Vandenput L, Langefeld C, Raffield L, Terry G, Cox AJ, Allison MA, Criqui MH, Bowden D, Ikram MA, Mellstrom D, Karlsson MK, Carr J, Budoff M, Phillips C, Cupples LA, Chou WC, Myers RH, Ralston SH, Gautvik KM, Cawthon PM, Cummings S, Karasik D, Rivadeneira F, Gudnason V, Orwoll ES, Harris TB, Ohlsson C, Kiel DP, Hsu YH. Novel Genetic Variants Associated With Increased Vertebral Volumetric BMD, Reduced Vertebral Fracture Risk, and Increased Expression of SLC1A3 and EPHB2. J Bone Miner Res. 2016;31(12):2085-97. doi: 10.1002/jbmr.2913. PubMed PMID: 27476799.
225. Putman MS, Greenblatt LB, Sicilian L, Uluer A, Lapey A, Sawicki G, Gordon CM, Bouxsein ML, Finkelstein JS. Young adults with cystic fibrosis have altered trabecular microstructure by ITS-based morphological analysis. Osteoporos Int. 2016;27(8):2497-505. doi: 10.1007/s00198-016-3557-z. PubMed PMID: 26952010; PMCID: PMC4947435.
224. Liu ES, Martins JS, Raimann A, Chae BT, Brooks DJ, Jorgetti V, Bouxsein ML, Demay MB. 1,25-Dihydroxyvitamin D Alone Improves Skeletal Growth, Microarchitecture, and Strength in a Murine Model of XLH, Despite Enhanced FGF23 Expression. J Bone Miner Res. 2016;31(5):929-39. doi: 10.1002/jbmr.2783. PubMed PMID: 26751835; PMCID: PMC4862933.
223. Devlin MJ, Brooks DJ, Conlon C, Vliet M, Louis L, Rosen CJ, Bouxsein ML. Daily leptin blunts marrow fat but does not impact bone mass in calorie-restricted mice. J Endocrinol. 2016;229(3):295-306. doi: 10.1530/JOE-15-0473. PubMed PMID: 27340200; PMCID: PMC5171226.
222. Bonaretti S, Vilayphiou N, Chan CM, Yu A, Nishiyama K, Liu D, Boutroy S, Ghasem-Zadeh A, Boyd SK, Chapurlat R, McKay H, Shane E, Bouxsein ML, Black DM, Majumdar S, Orwoll ES, Lang TF, Khosla S, Burghardt AJ. Operator variability in scan positioning is a major component of HR-pQCT precision error and is reduced by standardized training. Osteoporos Int. 2016. doi: 10.1007/s00198-016-3705-5. PubMed PMID: 27475931.
221. Bachmann KN, Schorr M, Bruno AG, Bredella MA, Lawson EA, Gill CM, Singhal V, Meenaghan E, Gerweck AV, Slattery M, Eddy KT, Ebrahimi S, Koman SL, Greenblatt JM, Keane RJ, Weigel T, Misra M, Bouxsein ML, Klibanski A, Miller KK. Vertebral Volumetric Bone Density and Strength are Impaired in Women with Low-weight and Atypical Anorexia Nervosa. J Clin Endocrinol Metab. 2016:jc20162099. doi: 10.1210/jc.2016-2099. PubMed PMID: 27732336.
220. Bachmann KN, Bruno AG, Bredella MA, Schorr M, Lawson EA, Gill CM, Singhal V, Meenaghan E, Gerweck AV, Eddy KT, Ebrahimi S, Koman SL, Greenblatt JM, Keane RJ, Weigel T, Dechant E, Misra M, Klibanski A, Bouxsein ML*, Miller KK*. Vertebral Strength and Estimated Fracture Risk Across the BMI Spectrum in Women. J Bone Miner Res. 2016;31(2):281-8. doi: 10.1002/jbmr.2697. PubMed PMID: 26332401; PMCID: PMC4833882. *Drs. Bouxsein and Miller are co-last authors
219. Anderson DE, Mannen EM, Sis HL, Wong BM, Cadel ES, Friis EA, Bouxsein ML. Effects of follower load and rib cage on intervertebral disc pressure and sagittal plane curvature in static tests of cadaveric thoracic spines. J Biomech. 2016;49(7):1078-84. doi: 10.1016/j.jbiomech.2016.02.038. PubMed PMID: 26944690; PMCID: PMC4851616.
218. Anderson DE, Quinn E, Parker E, Allaire BT, Muir JW, Rubin CT, Magaziner J, Hannan MT, Bouxsein ML, Kiel DP. Associations of Computed Tomography-Based Trunk Muscle Size and Density With Balance and Falls in Older Adults. J Gerontol A Biol Sci Med Sci. 2016;71(6):811-6. doi: 10.1093/gerona/glv185. PubMed PMID: 26503375; PMCID: PMC4888389.
217. Jonscher KR, Alfonso-Garcia A, Suhalim JL, Orlicky DJ, Potma EO, Ferguson VL, Bouxsein ML, Bateman TA, Stodieck LS, Levi M, Friedman JE, Gridley DS, Pecaut MJ. Spaceflight Activates Lipotoxic Pathways in Mouse Liver. PLoS One. 2016;11(4):e0152877. doi: 10.1371/journal.pone.0152877. PubMed PMID: 27097220; PMCID: PMC4838331.
216. Shanbhogue VV, Mitchell DM, Rosen CJ, Bouxsein ML. Type 2 diabetes and the skeleton: new insights into sweet bones. Lancet Diabetes Endocrinol. 2016;4(2):159-73. doi: 10.1016/S2213-8587(15)00283-1. PubMed PMID: 26365605.
215. Hughes JM, Popp KL, Yanovich R, Bouxsein ML, Matheny RW, Jr. The role of adaptive bone formation in the etiology of stress fracture. Exp Biol Med (Maywood). 2016. doi: 10.1177/1535370216661646. PubMed PMID: 27496801.
214. Tsai JN, Uihlein AV, Burnett-Bowie SM, Neer RM, Derrico NP, Lee H, Bouxsein ML, Leder BZ. Effects of Two Years of Teriparatide, Denosumab, or Both on Bone Microarchitecture and Strength (DATA-HRpQCT study). J Clin Endocrinol Metab. 2016;101(5):2023-30. doi: 10.1210/jc.2016-1160. PubMed PMID: 26964731; PMCID: PMC4870854.
213. Sis HL, Mannen EM, Wong BM, Cadel ES, Bouxsein ML, Anderson DE, Friis EA. Effect of follower load on motion and stiffness of the human thoracic spine with intact rib cage. J Biomech. 2016;49(14):3252-9. doi: 10.1016/j.jbiomech.2016.08.003. PubMed PMID: 27545081.
212. Rozental TD, Herder LM, Walley KC, Zurakowski D, Coyle K, Bouxsein ML, Wolf JM. 25-Hydroxyvitamin-D and Bone Turnover Marker Levels in Patients with Distal Radial Fracture. J Bone Joint Surg Am. 2015;97(20):1685-93. doi: 10.2106/JBJS.O.00313. PubMed PMID: 26491133.
211. Meng X, Bruno AG, Cheng B, Wang W, Bouxsein ML, Anderson DE. Effects of intervertebral joint stiffness magnitude and coupling on estimates of vertebral compressive loading and intervertebral translations. J Biomech Eng. 2015 Oct 137(10): 101008. PMCID: PMC4844232
210. Bruno AG, Bouxsein ML, Anderson DE. Development and validation of a musculoskeletal model of the fully articulated thoracolumbar spine and rib cage. J Biomech Eng. 2015;137(8). doi: 10.1115/1.4030408. PubMed PMID: 25901907.
209. Mitchell DM, Tuck P, Ackerman KE, Cano Sokoloff N, Woolley R, Slattery M, Lee H, Bouxsein ML, Misra M. Altered trabecular bone morphology in adolescent and young adult athletes with menstrual dysfunction. Bone. 2015;81:24-30. doi: 10.1016/j.bone.2015.06.021. PubMed PMID: 26123592.
208. Kiel DP, Hannan MT, Barton BA, Bouxsein ML, Sisson E, Lang T, Allaire B, Dewkett D, Carroll D, Magaziner J, Shane E, Leary ET, Zimmerman S, Rubin CT. Low-Magnitude Mechanical Stimulation to Improve Bone Density in Persons of Advanced Age: A Randomized, Placebo-Controlled Trial. J Bone Miner Res. 2015;30(7):1319-28. doi: 10.1002/jbmr.2448. PubMed PMID: 25581217.
207. Karim L, Van Vliet M, Bouxsein ML. Comparison of cyclic and impact-based reference point indentation measurements in human cadaveric tibia. Bone. 2015. doi: 10.1016/j.bone.2015.03.021. PubMed PMID: 25862290.
206. Fazeli PK, Faje AT, Cross EJ, Lee H, Rosen CJ, Bouxsein ML, Klibanski A. Serum FGF-21 levels are associated with worsened radial trabecular bone microarchitecture and decreased radial bone strength in women with anorexia nervosa. Bone. 2015;77:6-11. doi: 10.1016/j.bone.2015.04.001. PubMed PMID: 25868802; PMCID: 4447546.
205. Li J, Jafarpoor M, Bouxsein M, Rutkove SB. Distinguishing neuromuscular disorders based on the passive electrical material properties of muscle. Muscle Nerve. 2015;51(1):49-55. doi: 10.1002/mus.24270. PubMed PMID: 24752678; PMCID: 4201890.
204. Nawathe S, Nguyen BP, Barzanian N, Akhlaghpour H, Bouxsein ML, Keaveny TM. Cortical and trabecular load sharing in the human femoral neck. J Biomech. 2015;48(5):816-22. doi: 10.1016/j.jbiomech.2014.12.022. PubMed PMID: 25582355.
203. Yu EW, Bouxsein ML, Putman MS, Monis EL, Roy AE, Pratt JS, Butsch WS, Finkelstein JS. Two-year changes in bone density after Roux-en-Y gastric bypass surgery. J Clin Endocrinol Metab. 2015;100(4):1452-9. doi: 10.1210/jc.2014-4341. PubMed PMID: 25646793; PMCID: 4399296.
202. Nawathe S, Yang H, Fields AJ, Bouxsein ML, Keaveny TM. Theoretical effects of fully ductile versus fully brittle behaviors of bone tissue on the strength of the human proximal femur and vertebral body. J Biomech. 2015;48(7):1264-9. doi: 10.1016/j.jbiomech.2015.02.066. PubMed PMID: 25828400.
201. Wein MN, Spatz J, Nishimori S, Doench J, Root D, Babij P, Nagano K, Baron R, Brooks D, Bouxsein M, Pajevic PD, Kronenberg HM. HDAC5 controls MEF2C-driven sclerostin expression in osteocytes. J Bone Miner Res. 2015;30(3):400-11. doi: 10.1002/jbmr.2381. PubMed PMID: 25271055; PMCID: 4342334.
200. Yu EW, Putman MS, Derrico N, Abrishamanian-Garcia G, Finkelstein JS, Bouxsein ML. Defects in cortical microarchitecture among African-American women with type 2 diabetes. Osteoporos Int. 2015;26(2):673-9. doi: 10.1007/s00198-014-2927-7. PubMed PMID: 25398431; PMCID: 4400116.
199. Bala Y, Bui QM, Wang XF, Iuliano S, Wang Q, Ghasem-Zadeh A, Rozental TD, Bouxsein ML, Zebaze RM, Seeman E. Trabecular and cortical microstructure and fragility of the distal radius in women. J Bone Miner Res. 2015;30(4):621-9. doi: 10.1002/jbmr.2388. PubMed PMID: 25327362.
198. Tsai JN, Uihlein AV, Burnett-Bowie SA, Neer RM, Zhu Y, Derrico N, Lee H, Bouxsein ML, Leder BZ. Comparative effects of teriparatide, denosumab, and combination therapy on peripheral compartmental bone density, microarchitecture, and estimated strength: the DATA-HRpQCT Study. J Bone Miner Res. 2015;30(1):39-45. doi: 10.1002/jbmr.2315. PubMed PMID: 25043459; PMCID: 4396184.

Publications 2010 – 2014

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197. Devlin MJ, Van Vliet M, Motyl K, Karim L, Brooks DJ, Louis L, Conlon C, Rosen CJ, Bouxsein ML. Early-onset Type 2 diabetes impairs skeletal acquisition in the male TALLYHO/JngJ mouse. Endocrinology 2014; 155(10):3806-16.  PMID: 25051433.
196. Araujo AB, Yang M, Suarez EA, Dagincourt N, Abraham JR, Chiu G, Holick MF, Bouxsein ML, Zmuda JM. Racial/ethnic and socioeconomic differences in bone loss among men. J Bone Miner Res. 2014; 29(12):2552-60.  PMID 24984683.
195. Putman MS, Milliren CE, Derrico N, Uluer A, Sicilian L, Lapey A, Sawicki G, Gordon CM, Bouxsein ML, Finkelstein JS. Compromised bone microarchitecture and estimated bone strength in young adults with cystic fibrosis. J Clin Endocrinol Metab. 2014 Sep;99(9):3399-407.  PMID: 24926955.
194. Singhal V, Lawson EA, Ackerman KE, Fazeli PK, Clarke H, Lee H, Eddy K, Marengi DA, Derrico NP, Bouxsein ML, Misra M.  Irisin levels are lower in young amenorrheic athletes compared with eumenorrheic athletes and non-athletes and are associated with bone density and strength estimates.  PLoS One 2014; 9(6):e100218.  PMID: 24926783.
193. Mao XW, Pecaut MJ, Stodieck LS, Ferguson VL, Bateman TA, Bouxsein ML, Gridley DS.  Biological and metabolic response in STS-135 space-flown mouse skin.  Free Radic Res 2014 48(8):890-7.  PMID: 24796731.
192. Anderson DE, Bean JF, Holt NE, Keel JC, Bouxsein ML. Computed tomography-based muscle attenuation and electrical impedance myography as indicators of trunk muscle strength independent of muscle size in older adults. Am J Phys Med Rehab 2014; 93(7):553-61.  PMID: 24508931.
191 Fajardo RJ, Karim L, Calley VI, Bouxsein ML.  A review of rodent models of type 2 diabetic skeletal fragility.  J Bone Miner Res 2014; 29(5):1025-40.  PMID: 24585709.
190. Scheller EL, Troiano N, Vanhoutan JN, Bouxsein M, Fretz JA, Xi Y, Nelson T, Katz G, Berry R, Church CD, Doucette CR, Rodeheffer MS, Macdougald OA, Rosen CJ, Horowitz MC.  Use of osmium tetroxide staining with microcomputerized tomography to visualize and quantify bone marrow adipose tissue in vivo.  Methods Enzymol 2014; 537:123-39.
189. Zhao JJ, Lin J, Zhu D, Wang X, Brooks D, Chen M, Chu ZB, Takada K, Ciccarelli B, Admin S, Tao J, Tai YT, Treon S, Pinkus G, Kuo WP, Hideshima T, Bouxsein M, Munshi N, Anderson K, Carrasco R.  miR-30-5p functions as a tumor suppressor and novel therapeutic tool by targeting the oncogenic Wnt/?-catenin/BCL9 pathway.  Cancer Res 2014; 74(6):1801-13.
188. Fazeli PK, Wang IS, Miller KK, Herzog DB, Misra M, Lee H, Finkelstein JS, Bouxsein ML, Klibanski A. Teriparatide increases bone formation and bone mineral density in adult women with anorexia nervosa. J Clin Endocrinol Metab. 2014; 99(4):1322-9.  PMID: PMID: 24456286.
187. Zhu ED, Louis L, Brooks DJ, Bouxsein ML, Demay MB. Effect of bisphosphonates on the rapidly growing male murine skeleton. Endocrinology 2014; 155(4):1188-96.  PMID: 24422540.
186. Nawathe S, Akhlaghpour H, Bouxsein ML, Keaveny TM. Microstructural failure mechanisms in the human proximal femur for sideways fall loading. J Bone Miner Res 2014; 29(2):507-15.
185. Ellman RE, Grasso DJ, van Vliet M, Brooks DJ, Spatz JM, Conlon C, Bouxsein ML. Combined effects of botulinum toxin injection and hind limb unloading on bone and muscle. Calcif Tissue Int 2014; 94(3):327-37.  PMID: 24240478.
184. Bruno AG, Broe KE, Zhang X, Samelson EJ, Meng CA, Manoharan R, D’Agostino J, Cupples LA, Kiel DP, Bouxsein ML. Vertebral size, bone density, and strength in men and women matched for age and areal spine BMD.  J Bone Miner Res. 2014; 29(3):562-9.  PMID: 23955966.
183. Anderson DE, Demissie S, Allaire BT, Bruno AG, Kopperdahl DL, Keaveny TM, Kiel DP, Bouxsein ML. The associations between QCT-based vertebral bone measurements and prevalent vertebral fractures depend on the spinal locations of both bone measurement and fracture. Osteoporos Int. 2014; 25(2):559-66. PMID: 23925651.
182. Yu E, Bouxsein ML, Roy AE, Baldwin C, Cange A, Neer RM, Kaplan LM, Finkelstein JS. Bone loss after bariatric surgery: discordant results between DXA and QCT bone density. J Bone and Miner Res. 2014; 29(3):542-50. PMID: 23929784.
181. Sung M, Li J, Spieker AJ, Spatz J, Ellman R, Ferguson VL, Bateman TA, Rosen GD, Bouxsein ML, Rutkove SB. Spaceflight and hind limb unloading induce similar changes in electrical impedance characteristics of mouse gastrocnemius muscle. J Musculoskeletal Neuronal Interact. 2013 Dec 13(4):405-11.
180. Lewiecki EM, Adler RA, Bilezikian JP, Bouxsein ML, Marcus R, McClung MR, Miller PD, Tanner SB, Randall S. Osteoporosis update from the 2012 Santa Fe Bone Symposium. J Clin Densitom. 2013; 16(4):584-600.
179. Putman MS, Yu EW, Lee H, Neer RM, Schindler E, Taylor AP, Cheston E, Bouxsein ML, Finkelstein JS. Differences in skeletal microarchitecture and strength in African-American and Caucasian women. J Bone Miner Res. 2013; 28(10):2177-2185.
178. Motyl KJ, Bishop KA, Demambro VE, Bornstein SA, Le P, Kawai M, Lotinun S, Horowitz MC, Baron R, Bouxsein ML, Rosen CJ.   Altered thermogenesis and impaired bone remodeling in Misty mice. J Bone Miner Res 2013; 28(9):1885-97.
177. Fazeli PK, Ackerman KE, Pierce L, Guereca G, Bouxsein M, Misra M. Sclerostin and Pref-1 have differential effects on bone mineral density and strength parameters in adolescent athletes compared with non-athletes. Osteoporos Int. 2013; 24(9): 2433-40.
176. Bernhard JM, Edgcomb VP, Visscher PT, McIntyre-Wressnig A, Summons RE, Bouxsein ML, Louis L, Jeglinski M. Insights into foraminiferal influences on microfabrics of microbialites at Highborne Cay, Bahamas. Proc Natl Acad Sci U S A 2013; 110(24):9830-4.
175. Rozental TD, Deschamps LN, Taylor A, Earp B, Zurakowski D, Day CS, Bouxsein ML. Premenopausal women with a distal radial fracture have deteriorated trabecular bone density and morphology compared with controls without a fracture. J Bone Joint Surg Am 2013; 95(7):633-42.
174. Faje AT, Karim L, Taylor A, Lee H, Miller KK, Mendes N, Meenaghan E, Goldstein MA, Bouxsein ML, Misra M, Klibanski A. Adolescent girls With anorexia nervosa have impaired cortical and trabecular microarchitecture and lower estimated bone strength at the distal radius. J Clin Endocrinol Metab. 2013; 98(5):1923-9.
173. Kacena MA, Gundberg CM, Kacena WJ, 3rd, Landis WJ, Boskey AL, Bouxsein ML, Horowitz MC. The effects of GATA-1 and NF-E2 deficiency on bone biomechanical, biochemical, and mineral properties. J Cell Physiol. 2013; 228(7):1594-600
172 Karim L, Hussein A, Morgan E, Bouxsein ML.  Bone Biomechanics. In: Marcus R, Feldman D, Nelson D, Dempster D (eds.) Osteoporosis, Fourth Edition ed., vol. I. Elsevier Academic Press, San Diego, CA. 2013; pp. 431-452.
171 Anderson DE, Bruno AG, Bouxsein ML. Biomechanics of Age-Related Fractures. In: Marcus R, Feldman D, Nelson D, Dempster D (eds.) Osteoporosis, Fourth Edition ed., vol. I. Elsevier Academic Press, San Diego, CA. 2013;  pp. 497-516.
170. Roux JP, Wegrzyn J, Boutroy S, Bouxsein ML, Hans D, Chapurlat R. The predictive value of trabecular bone score (TBS) on whole lumbar vertebrae mechanics: an ex vivo study. Osteoporos Int. 2013; 24(9):2455-60
169. Devlin MJ, Grasemann C, Cloutier AM, Louis L, Alm C, Palmert MR, Bouxsein ML. Maternal perinatal diet induces developmental programming of bone architecture. J Endocrinol 2013; 217(1):69-81.
168 Marcus R, Dempster D and Bouxsein ML. The Nature of Osteoporosis. In Osteoporosis Fourth Edition, ed:  R Marcus, J Kelsey, C Rosen and D Feldman, Academic Press, Inc., San Diego. 2013; pp 21-30.
167. Spatz JM, Ellman R, Cloutier AM, Louis L, van Vliet M, Suva LJ, Dwyer D, Stolina M, Ke HZ, Bouxsein ML. Sclerostin antibody inhibits skeletal deterioration due to reduced mechanical loading. J Bone Miner Res 2013; 28(4):865-74.
166. Ellman R, Spatz J, Cloutier A, Palme R, Christiansen BA, Bouxsein ML. Partial reductions in mechanical loading yield proportional changes in bone density, bone architecture, and muscle mass. J Bone Miner Res 2013; 28(4):875-85.
165 Anderson DE, Bouxsein ML. Factor of Risk for Fracture. In: Silva MJ, Guo XE (eds.) Skeletal Aging and Osteoporosis: Biomechanics and Mechanobiology. Springer, Verlag, 2013; pp 133-150.
164. Burghardt AJ, Pialat JB, Kazakia GJ, Boutroy S, Engelke K, Patsch JM, Valentinitsch A, Liu D, Szabo E, Bogado CE, Zanchetta MB, McKay HA, Shane E, Boyd SK, Bouxsein ML, Chapurlat R, Khosla S, Majumdar S. Multicenter precision of cortical and trabecular bone quality measures assessed by high-resolution peripheral quantitative computed tomography. J Bone Miner Res 2013; 28(3):524-36.
163. Anderson DE, D’Agostino JM, Bruno AG, Demissie S, Kiel DP, Bouxsein ML.Variations of CT-Based Trunk Muscle Attenuation by Age, Sex, and Specific Muscle. J Gerontol A Biol Sci Med Sci 2013; 68(3):317-23.
162. Lawson EA, Ackerman K, Estella NM, Guereca G, Pierce L, Sluss PM, Bouxsein ML, Klibanski A, Misra M. Nocturnal oxytocin secretion is lower in amenorrheic athletes than non-athletes and associated with bone microarchitecture and finite element analysis parameters. Eur J Endocrinol. 2013; 168(3):457-64.
161. Burghardt AJ, Pialat JB, Kazakia GJ, Boutroy S, Engelke K, Patsch JM, Valentinitsch A, Liu D, Szabo E, Bogado CE, Zanchetta MB, McKay HA, Shane E, Boyd SK, Bouxsein ML, Chapurlat R, Khosla S, Majumdar S. Multi-center precision of cortical and trabecular bone quality measures assessed by HR-PQCT. J Bone Miner Res 2013; 28(3):524-36
160. Fajardo RJ, Desilva JM, Manoharan RK, Schmitz JE, Maclatchy LM, Bouxsein ML. Lumbar vertebral body bone microstructural scaling in small to medium-sized strepsirhines. Anat Rec (Hoboken) 2013; 296(2):210-26.
159. Spatz JM, Fields EE, Yu EW, Divieti Pajevic P, Bouxsein ML, Sibonga JD, Zwart SR, Smith SM. Serum sclerostin increases in healthy adult men during bed rest. J Clin Endocrinol Metab 2012; 97(9):E1736-40.
158. Samelson EJ, Christiansen BA, Demissie S, Broe KE, Louie-Gao Q, Cupples LA, Roberts BJ, Manoharam R, D’Agostino J, Lang T, Kiel DP, Bouxsein ML.  QCT measures of bone strength at the thoracic and lumbar spine: the Framingham Study. J Bone Miner Res 2012; 27(3):654-63.
157. Portero-Muzy NR, Chavassieux PM, Bouxsein ML, Gineyts E, Garnero P, Chapurlat RD. Early effects of zoledronic acid and teriparatide on bone microarchitecture, remodeling and collagen crosslinks: Comparison between iliac crest and lumbar vertebra in ewes. Bone 2012; 51(4):714-9
156. Pierroz DD, Bonnet N, Bianchi EN, Bouxsein ML, Baldock PA, Rizzoli R, Ferrari SL. Deletion of beta-adrenergic receptor 1, 2, or both leads to different bone phenotypes and response to mechanical stimulation. J Bone Miner Res 2012; 27(6):1252-62.
155. Liu CT, Karasik D, Zhou Y, Hsu YH, Genant HK, Broe KE, Lang TF, Samelson EJ, Demissie S, Bouxsein ML, Cupples LA, Kiel DP. Heritability of prevalent vertebral fracture and volumetric bone mineral density and geometry at the lumbar spine in three generations of the Framingham study. J Bone Miner Res 2012; 27(4):954-8.
154. Lane SW, De Vita S, Alexander KA, Karaman R, Milsom MD, Dorrance AM, Purdon A, Louis L, Bouxsein ML, Williams DA. Rac signaling in osteoblastic cells is required for normal bone development but is dispensable for hematopoietic development. Blood 2012; 119(3):736-44.
153. Kim YM, Demissie S, Genant HK, Cheng X, Yu W, Samelson EJ, Kiel DP, Bouxsein ML. Identification of prevalent vertebral fractures using CT lateral scout views: a comparison of semi-automated quantitative vertebral morphometry and radiologist semi-quantitative grading. Osteoporos Int 2012; 23(3):1007-16.
152. Grasemann C, Devlin MJ, Rzeczkowska PA, Herrmann R, Horsthemke B, Hauffa BP, Grynpas M, Alm C, Bouxsein ML, Palmert MR. Parental diabetes: the akita mouse as a model of the effects of maternal and paternal hyperglycemia in wildtype offspring. PLoS One 2012; 7(11):e50210.
151 Devlin MJ, Bouxsein ML. Influence of pre- and peri-natal nutrition on skeletal acquisition and maintenance. Bone 2012; 50(2):444-51.
150. Dufour AB, Roberts B, Broe KE, Kiel DP, Bouxsein ML, Hannan MT. The factor-of-risk biomechanical approach predicts hip fracture in men and women: the Framingham Study. Osteoporos Int 2012 ; 23(2):513-20.
149. Bruno AG, Anderson DE, D’Agostino J, Bouxsein ML. The effect of thoracic kyphosis and sagittal plane alignment on vertebral compressive loading. J Bone Miner Res 2012; 27(10):2144-51.
148. Bredella MA, Lin E, Gerweck AV, Landa MG, Thomas BJ, Torriani M, Bouxsein ML, Miller KK.  Determinants of bone microarchitecture and mechanical properties in obese men. J Clin Endocrinol Metab 2012; 97(11):4115-22.
147. Braun TP, Orwoll B, Zhu X, Levasseur PR, Szumowski M, Nguyen ML, Bouxsein ML, Klein RF, Marks DL. Regulation of lean mass, bone mass, and exercise tolerance by the central melanocortin system. PLoS One 2012; 7(7):e42183.
146. Baud’huin M, Solban N, Cornwall-Brady M, Sako D, Kawamoto Y, Liharska K, Lath D, Bouxsein ML, Underwood KW, Ucran J, Kumar R, Pobre E, Grinberg A, Seehra J, Canalis E, Pearsall RS, Croucher PI. A soluble bone morphogenetic protein type IA receptor increases bone mass and bone strength. Proc Natl Acad Sci U S A 2012; 109(30):12207-12.
145. Anderson DE, D’Agostino JM, Bruno AG, Manoharan RK, Bouxsein ML. Regressions for estimating muscle parameters in the thoracic and lumbar trunk for use in musculoskeletal modeling. J Biomech 2012; 45(1):66-75.
144. Ackerman KE, Putman M, Guereca G, Taylor AP, Pierce L, Herzog DB, Klibanski A, Bouxsein M, Misra M. Cortical microstructure and estimated bone strength in young amenorrheic athletes, eumenorrheic athletes and non-athletes. Bone 2012; 51(4):680-7.
143. Guntur AR, Kawai M, Le P, Bouxsein ML, Bornstein S, Green CB, Rosen CJ. An essential role for the circadian-regulated gene nocturnin in osteogenesis: the importance of local timekeeping in skeletal homeostasis. Ann N Y Acad Sci 2011; 1237:58-63.
142. Boonen S, Wahl DA, Nauroy L, Brandi ML, Bouxsein ML, Goldhahn J, Lewiecki EM, Lyritis GP, Marsh D, Obrant K, Silverman S, Siris E, Akesson K. Balloon kyphoplasty and vertebroplasty in the management of vertebral compression fractures. Osteoporos Int 2011; 22(12):2915-34.
141. Ackerman KE, Nazem T, Chapko D, Russell M, Mendes N, Taylor AP, Bouxsein ML, Misra M Bone microarchitecture is impaired in adolescent amenorrheic athletes compared with eumenorrheic athletes and nonathletic controls. J Clin Endocrinol Metab 2011; 96(10):3123-33.
140. Kawai M, Breggia AC, Demambro VE, Shen X, Canalis E, Bouxsein ML, Beamer WG, Clemmons DR, Rosen CJ. The heparin-binding domain of IGFBP-2 has IGF binding-independent biologic activity in the growing skeleton. J Biol Chem. 2011; 286 (16): 14670-80.
139. Kim YM, Demissie S, Eisenberg R, Samelson EJ, Kiel DP, Bouxsein ML. Intra-and inter-reader reliability of semi-automated quantitative morphometry measurements and vertebral fracture assessment using lateral scout views from computed tomography. Osteoporos Int. 2011; 22 (10): 2677-88.
138. Craig ZR, Marion SL, Funk JL, Bouxsein ML, Hoyer PB. Retaining ovarian tissue following ovarian failure has limited influence on bone loss in aged mice. J Osteoporos. Published online 2010 June 29. doi:  10.4061/2010/157323
137. Christiansen BA, Kopperdahl DL, Kiel DP, Keaveny TM, Bouxsein ML.  Mechanical contributions of the cortical and trabecular compartments contribute to differences in age-related changes in vertebral body strength in men and women assessed by QCT-based finite element analysis. J Bone Miner Res. 2011; 26(5):974-83.
136 Rizzoli R, Akesson K, Bouxsein M, Kanis JA, Napoli N, Papapoulos S, Reginster JY, Cooper C. Subtrochanteric fractures after long-term treatment with bisphosphonates: a European Society on Clinical and Economic Aspects of Osteoporosis and Osteoarthritis, and International Osteoporosis Foundation Working Group Report. Osteoporos Int 2011; 22(2):373-90.
135. Wegrzyn J, Roux JP, Arlot ME, Boutroy S, Vilayphiou N, Guyen O, Delmas PD, Chapurlat R, Bouxsein ML. Determinants of the mechanical behavior of human lumbar vertebrae after simulated mild fracture. J Bone Miner Res. 2011; 26(4):739-46.
134. Follet H, Viguet-Carrin S, Burt-Pichat B, Depalle B, Bala Y, Gineyts E, Munoz F, Arlot M, Boivin G, Chapurlat R, Delmas PD, Bouxsein ML. Effects of preexisting microdamage, collagen cross-links, degree of mineralization, age and architecture on compressive mechanical properties of elderly human vertebral trabecular bone. J Orthop Res. 2011; 29(4):481-8.
133 Bouxsein ML 2011 Bone structure and fracture risk: do they go arm in arm? J Bone Miner Res 26(7):1389-91.
132. Samelson EJ, Christiansen BA, Demissie S, Broe KE, Zhou Y, Meng CA, Yu W, Cheng X, O’Donnell CJ, Hoffmann U, Genant HK, Kiel DP, Bouxsein ML. Reliability of vertebral fracture assessment using multidetector CT lateral scout views: the Framingham Osteoporosis Study. Osteoporos Int. 2011; 22(4):1123-31.
131. Jones M, Liu JC, Barthel TK, Hussain S, Lovria E, Cheng D, Schoonmaker JA, Mulay S, Ayers DC, Bouxsein ML, Stein GS, Mukherjee S, Lian JB. A Proteasome Inhibitor, Bortezomib, Inhibits Breast Cancer Growth and Reduces Osteolysis by Downregulating Metastatic Genes. Clin Cancer Res. 2010; 16(20): 4978-89.
130. Iyer S, Christiansen BA, Roberts BJ, Valentine MJ, Manoharan RK, Bouxsein ML. A biomechanical model for estimating loads on thoracic and lumbar vertebrae. Clin Biomech (Bristol, Avon). 2010; 25(9):853-8.
129. Wegrzyn J, Roux JP, Arlot ME, Boutroy S, Vilayphiou N, Guyen O, Delmas PD, Chapurlat R, Bouxsein ML. Role of trabecular microarchitecture and its heterogeneity parameters in the mechanical behavior of ex-vivo human L3 vertebrae. J Bone Miner Res. 2010; 25(11): 2324-31.
128. Chantry AD, Heath D, Mulivor AW, Pearsall S, Baud’huin M, Coulton L, Evans H, Abdul N, Werner ED, Bouxsein ML, Key ML, Seehra J, Arnett TR, Vanderkerken K, Croucher P. Inhibiting activin-A signaling stimulates bone formation and prevents cancer induced bone destruction in vivo. J Bone Miner Res. 2010; 25(12): 2357-70.
127. Kiel DP, Hannan MT, Barton BA, Bouxsein ML, Lang TF, Brown KM, Shane E, Magaziner J, Zimmerman S, Rubin CT. Insights from the conduct of a device trial in older persons: low magnitude mechanical stimulation for musculoskeletal health. Clin Trials. 2010; 7(4):354-67.
126. Wagner EB, Granzella NP, Saito H, Newman DJ, Young LR, Bouxsein ML. Partial weight suspension: a novel murine model for investigating adaptation to reduced musculoskeletal loading. J Appl Physiol 2010; 109(2):350-7.
125. Devlin MJ, Cloutier AM, Thomas NA, Panus DA, Lotinun S, Pinz I, Baron R, Rosen CJ, Bouxsein ML. Caloric restriction leads to high marrow adiposity and low bone mass in growing mice. J Bone Miner Res 2010; 25(9):2078-88.
124. Roberts BJ, Thrall E, Muller J, Bouxsein ML. Comparison of hip fracture risk by femoral aBMD to experimentally measured factor of risk. Bone 2010; 46(3):742-6.
123. Guo J, Liu M, Yang D, Bouxsein ML, Saito H, Galvin RJ, Kuhstoss SA, Thomas CC, Schipani E, Baron R, Bringhurst FR, Kronenberg HM. Suppression of Wnt signaling by Dkk1 attenuates PTH-mediated stromal cell response and new bone formation. Cell Metab 2010; 11(2):161-71.
122. Lotinun S, Pearsall RS, Davies MV, Marvell TH, Monnell TE, Ucran J, Fajardo RJ, Kumar R, Underwood KW, Seehra J, Bouxsein ML, Baron R. A soluble activin receptor Type IIA fusion protein (ACE-011) increases bone mass via a dual anabolic-antiresorptive effect in Cynomolgus monkeys. Bone 2010; 46(4):1082-8.
121 Bouxsein ML, Boyd SK, Christiansen BA, Guldberg RE, Jepsen KJ, Muller R. Guidelines for assessment of bone microstructure in rodents using micro-computed tomography. J Bone Miner Res. 2010; 25(7):1468-86.
120. Viguet-Carrin S, Follet H, Gineyts E, Roux JP, Munoz F, Chapurlat R, Delmas PD, Bouxsein ML. Association between collagen cross-links and trabecular microarchitecture properties of human vertebral bone. Bone 2010; 46(2):342-7.
119. Seeherman HJ, Li XJ, Bouxsein ML, Wozney JM. rhBMP-2 induces transient bone resorption followed by bone formation in a nonhuman primate core-defect model. J Bone Joint Surg (Am). 2010; 92(2):411-26.
118. Shomento SH, Wan C, Cao X, Faugere MC, Bouxsein ML, Clemens TL, Riddle RC. Hypoxia-inducible factors 1alpha and 2alpha exert both distinct and overlapping functions in long bone development. J Cell Biochem 2010; 109(1):196-204.
117. Guo J, Liu M, Yang D, Bouxsein ML, Thomas CC, Schipani E, Bringhurst FR, Kronenberg HM. Phospholipase C signaling via the parathyroid hormone (PTH)/PTH-related peptide receptor is essential for normal bone responses to PTH. Endocrinology 2010; 151(8):3502-13.
116. Fajardo RJ, Manoharan RK, Pearsall RS, Davies MV, Marvell T, Monnell TE, Ucran JA, Pearsall AE, Khanzode D, Kumar R, Underwood KW, Roberts B, Seehra J, Bouxsein ML.  Treatment with a soluble receptor for activin improves bone mass and structure in the axial and appendicular skeleton of female cynomolgus macaques (Macaca fascicularis). Bone. 2010; 46(1): 64-71.
115 Christiansen BA and Bouxsein ML Biomechanics of vertebral fractures and the vertebral fracture cascade. Curr Osteoporos Rep 2010; 8(4):198-204.
114. Roux J, Wegrzyn J, Arlot M, Guyen O, Delmas P, Chapurlat R, Bouxsein M. Contribution of trabecular and cortical components to biomechanical behavior of human vertebrae: an ex-vivo study.  J Bone Miner Res. 2010; 25(2): 356-61.
113. Fritton JC, Emerton KB, Sun H, Kawashima Y, Mejia W, Wu Y, Rosen CJ, Panus D, Bouxsein ML, Majeska RJ, Schaffler MB, Yakar S. Growth hormone protects against ovariectomy-induced bone loss in states of low circulating IGF-1. J Bone Min Res. 2010; 25(2):235-46.
112. Borah B, Dufresne T, Nurre J, Phipps R, Chmielewski P, Wagner L, Lundy M, Bouxsein M, Zabeze R, Seeman E. Risedronate reduces intracortical porosity in women with osteoporosis. J Bone Min Res. 2010; 25(1):41-7.

Publications 2005 – 2009

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111. Pozzi S, Vallet S, Mukherjee S, Cirstea D, Vaghela N, Santo L, Rosen E, Ikeda H, Okawa Y, Kiziltepe T, Schoonmaker J, Xie W, Hideshima T, Weller E, Bouxsein ML, Munshi NC, Anderson KC, Raje N. Clin Cancer Res; 15(18): 5829-39. PDF
110. Sornay-Rendu E, Boutroy S, Munoz F, Bouxsein ML. Cortical and trabecular architecture are altered in postmenopausal women with fractures. Osteop Int 2009; 20(8): 1291-97. PDF
109. Bouxsein M, Chen P, Glass E, Kallmes D, Delmas P, Mitlak B. Teriparatide and raloxifene reduce the risk of new adjacent vertebral fractures in postmenopausal women with osteoporosis: Results from two randomized, controlled trials. J Bone Jt Surg (Am) 2009; 91(6): 1321-28. PDF
108. Rozental TD, Vazquez MA, Chacko AT, Ayogu N, Bouxsein ML. Comparison of radiographic fracture healing in the distal radius for patients on and off bisphosphonate therapy. J Hand Surg Am 2009; 34(4): 595-602. PDF
107. Yakar S, Canalis E, Sun H, Mejia W, Kawashima Y, Nasser P, Courtland HW, Williams V, Bouxsein M, Rosen C, Jepsen KJ. Serum IFG-1 determines skeletal strength by regulating sub-periosteal expansion and trait interactions. J Bone Min Res 2009; 24(8): 1481-92. PDF
106. Kirmani S, Christen D, van Lenthe GH, Fischer PR, Bouxsein ML, McCready LK, Melton LJ, Riggs BL, Amin S, Muller R, Khosla S. Bone structure at the distal radius during adolescent growth. J Bone Min Res 2009; 24(6):1033-42. PDF
105. Brouwers JEM, Ruchelsman M, van Rietbergen B, Bouxsein ML. Determination of rat vertebral bone compressive fatigue properties in untreated intact rats and zoledronic acid treated, ovariectomized rats. Osteop Int 2009; 20(8):1377-84. PDF
104. Pierroz DD, Rufo A, Bianchi EN, Glatt V, Capulli M, Rucci N, Cavat F, Rizzoli R, Teti A, Bouxsein ML, Ferrari SL. Beta-arrestin2 regulates RANKL and Ephrins gene expression in response to bone remodeling in mice. J Bone Min Res 2009; 24(5); 775-84. PDF
103. Nielson CM, Bouxsein ML, Freitas SS, Ensrud KE, Orwoll ES; for the Osteoporotic Fractures in Men (MrOS) Research Group. Trochanteric soft tissue thickness and hip fracture in older men. J Clin Endocrinol Metab 2009; 94(2): 491-6. PDF
102. Yakar S, Rosen CJ, Bouxsein ML, Sun H, Mejia W, Kawashima Y, Wu Y, Emerton K, Williams V, Jepsen K, Schaffler MB, Majeska RJ, Gavrilova O, Gutierrez M, Hwang D, Pennisi P, Frystyk J, Boisclair Y, Pintar J, Jasper H, Domene H, Cohen P, Clemmons D, Leroith D. Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism. FASEB J 2009; 23(3):709-19. PDF
101. Fajardo RJ, Cory E, Patel ND, Nazarian A, Laib A, Manoharan RK, Schmitz JE, Desilva JM, Maclatchy LM, Snyder BD, Bouxsein ML. Specimen size and porosity can introduce error into μCT-based tissue mineral density measurements. Bone 2009; 44(1):176-84 PDF
100. Bouxsein ML, Devlin MD, Glatt V, Dhillon H, Pierroz DP, Ferrari SL. Mice lacking β-adrenergic receptors have increased bone mass, but are not protected from deleterious skeletal effects of ovariectomy. Endocrinology 2009. 150(1): 144-52. PDF
99. Yu PB, Deng DY, Lai CS, Hong CC, Cuny GD, Bouxsein ML, Hong DW, McManus PM, Katagiri T, Sachidanandan C, Fukuda T, Mishina Y, Peterson RT, Block KD. BMP Type I receptor inhibition prevents ectopic ossification in a mouse model of fibrodysplasia ossificans progressiva. Nature Med 2008; Dec14(12):1363-9.
98. Okazaki M, Ferrandon S, Vilardaga JP, Bouxsein ML, Potts JT Jr, Gardella TJ. Prolonged signaling at the parathyroid hormone receptor by peptide ligands targeted to a specific receptor conformation. Proc Natl Acad Sci U S A. 2008; 105(43):16525-30.
97. Melton LJ 3rd, Riggs BL, Leibson CL, Achenbach SJ, Camp JJ, Bouxsein ML, Atkinson EJ, Robb RA, Khosla S. A bone structural basis for fracture risk in diabetes. J Clin Endocrinol Metab 2008; 93(12): 4804-9
96. Brouwers JEM, Ruchelsman R, van Rietbergen B, Bouxsein ML. Influence of early and late zoledronic acid administration on vertebral structure and strength in ovariectomized rats. Calcified Tissue Int 2008; Sep;83(3):186-91.
95. Berman SD, Calo E, Landman AS, Danielian PS, Miller ES, West JC, Fonhoue BD, Caron A, Bronson R, Bouxsein ML, Mukherjee S, Lees JA. Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage. Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11851-6.
94. Arlot M, Burt-Pichat B, Roux J, Vashisht D, Bouxsein M, Delmas PD. Microarchitecture influences microdamage accumulation in human vertebral trabecular bone. J Bone Min Res 2008; 23(10):1613-8.
93. Ackert-Bicknell CL, Demissie S, de Evsikova CM, Hsu YH, Demambro VE, Karasik D, Cupples LA, Ordovas JM, Tucker KL, Cho K, Canalis E, Paigen B, Churchill GA, Forejt J, Beamer WG, Ferrari S, Bouxsein ML, Kiel DP, Rosen CJ. A PPARG by dietary fat interaction influences bone mass in mice and humans. J Bone Min Res 2008; 23(9):1398-408.
92. Keaveny TM and Bouxsein ML. Theoretical implications of the biomechanical fracture threshold. J Bone Min Res 2008; 23(10):1541-7.
91. O’Brien CA, Plotkin LI, Galli C, Goellner JJ, Gortazar AR, Allen MR, Robling A, Bouxsein M, Schipani E, Turner CH, Jilka RL, Weinstein RS, Manolagas SC, Bellido T. Control of bone mass and remodeling by PTH receptor signaling in osteocytes. PLoS One 2008 Aug 13; 3 (8) e2942.
90. Black DM, Bouxsein ML, Marshall LM, Cummings SR, Lang TF, Cauley JA, Ensrud KE, Nielson CM, Orwoll ES. Proximal femoral structure and the prediction of hip fracture in men: a large prospective study using quantitative computed tomography. J Bone Min Res; 2008; 23 (8): 1326-33.
89. Wright LE, Christian PJ, Rivera Z, Van Alstine WG, Funk JL, Bouxsein ML, Hoyer PB. Comparison of skeletal effects of ovariectomy versus chemically-induced ovarian failure in mice. J Bone Min Res 2008; 23 (8):1296-1303.
88. Bouxsein ML and Delmas PD. Considerations for development of surrogate endpoints for anti-fracture efficacy of new treatments in osteoporosis: a perspective. J Bone Min Res 2008; 23 (8): 1155-67.
87. Davey RA, Turner AG, McManus JF, Chiu WSM, Tjahyono F, Moore AJ, Atkins GJ, Anderson PH, Ma C, Glatt V, MacLean HE, Vincent C, Bouxsein M, Morris HA, Findlay DM, Zajac JD. Calcitonin receptor plays a physiological role to protect against hypercalcemia in mice. J Bone Min Res 2008; 23 (8); 1182-93.
86. Shimada M, Greer PA, McMahon AP, Bouxsein ML, Schipani E. In vivo targeted deletion of calpain small subunit, Capn4, in cells of the osteoblast lineage impairs cell proliferation, differentiation, and bone formation. 2008; J Biol Chem 2008; 283 (30): 21002-10.
85. Pearsall RA, Canalis E, Corwall-Brady M, Underwood KW, Haigis B, Ucran J, Kumar R, Pobre E, Brinberg A, Werner ED, Glatt V, Stadmeyer L, Smith D, Seehra J, Bouxsein ML. A soluble activin type IIA receptor induces bone formation and improves skeletal integrity. Proc Natl Acad Sci USA 2008; 105 (19): 7082-7.
84. Rosental TD, Makhni EC, Day CS, Bouxsein ML. Improving evaluation and treatment for osteoporosis following distal radial fractures. A prospective randomized intervention. J Bone Joint Surg Am 2008; 90 (5): 953-61.
83. DeMambro VE, Clemmons Dr, Horton LG, Bouxsein ML, Wood TL, Beamer WG, Canalis E, Rosen CJ. Gender-specific changes in bone turnover and skeletal architecture in ifgbp-2 null mice. Endocrinology 2008; 149(5): 2051-61.
82. Black DM, Bouxsein ML, Palermo L, McGowan JA, Newitt DC, Rosen E, Majumdar S, Rosen CJ. Randomized trial of once-weekly parathyroid hormone (1-84) on bone mineral density and remodeling. J Clin Endocrinol Metab 2008; 93 (6): 2166-72.
81. McManus JF, Davey RA, Maclean HE, Doust EA, Chia WS, Sims NA, Bouxsein ML, Glatt V, Zajac JD, Danks JA. Intermittent Fugu parthyroid hormone 1 (1-34) is an anabolic bone agent in young male rats and osteopenic ovariectomized rats. Bone 2008; 42 (6): 1164-74.
80. Mukherjee S, Raje N, Schoonmaker JA, Liu JC, Hideshima T, Wein MN, Jones DC, Vallet S, Bouxsein ML, Pozzi S, Chhetri S, Seo YD, Aronson JP, Patel C, Fulciniti M, Purton LE, Glimcher LH, Lian JB, Stein G, Anderson KC, Scadden DT. Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in mice. J Clin Inv 2008; 118 (2): 491-504.
79. Boutroy S, van Rietbergen B, Sornay-Rendu E, Munoz F, Bouxsein ML, Delmas PD. Finite element analysis based on in vivo HR-pQCT images of the distal radius is associated with wrist fracture in postmenopausal women. J Bone Min Res 2008; 23 (3): 392-99.
78. Betz OB, Betz VM, Nazarian A, Egermann M, Gerstenfeld LC, Einhorn TA, Vrahas MS, Bouxsein ML, Evans CH. Delayed administration of adenoviral BMP-2 improves the formation of bone in osseous defects. Gene Ther 2007; 14 (13): 1039-44.
77. Betz VM, Betz OB, Glatt V, Gerstenfeld LC, Einhorn TA, Bouxsein ML, Vrahas MS, Evans CH. Healing of segmental bone defects by direct percutaneous gene delivery: Effect of vector dose. Hum Gene Ther 2007; 18 (10): 907-15.
76. Melton LJ, Riggs BL, Keaveny TM, Achenbach SJ, Hoffman PF, Camp JJ, Rouleau PA, Bouxsein ML, Amin S, Atkinson EJ, Robb RA, Khosla S. Structural determinants of vertebral fracture risk. J Bone Min Res 2007, 22 (12): 1885-92.
75. Kostenuik P, Ferrari S, Pierroz D, Bouxsein M, Morony S, Warmington KS, Adamu S, Geng Z, Grisanti M, Shalhoub V, Martin S, Biddlecome G, Shimamoto G, Boone T, Shen V.Lacey D. Infrequent delivery of a long-acting PTH-Fc fusion protein has potent anabolic effects on cortical and cancellous bone. J Bone Min Res 2007; 22 (10): 1534-47.
74. Melton LJ, Riggs BL, van Lenthe GH, Achenbach SJ, Muller R, Bouxsein ML, Amin S, Atkinson EJ, Khosla S. Contribution of in vivo structural measurements and load/strength ratios to the determination of forearm fracture risk in postmenopausal women. J Bone Min Res 2007; 22(9): 1442-8.
73. Tsiridis E, Morgan EF, Bancroft JM, Song M, Kain M, Gerstenfeld L, Einhorn TA, Bouxsein ML, Tornetta P. Effects of OP-1 and PTH in a new experimental model for the study of metaphyseal bone healing. J Orthop Res 2007; 25 (9): 1193-1203.
72. Glatt V, Canalis E, Stadmeyer L, Bouxsein ML. Age-related changes in trabecular architecture differ in female and male C57BL/6J mice. J Bone Min Res 2007; 22 (8): 1197-1207.
71. Betz OB, Betz VM, Nazarian A, Egermann M, Gerstenfeld LC, Einhorn TA, Verhas MS, Bouxsein ML, Evans CH. Delayed administration of adenoviral BMP-2 vector improves the formation of bone in osseous defects. Gene Ther 2007; 14 (13): 1039-44.
70. Wang Y, Wan C, Liu X, Cao X, Bouxsein ML, Faugere M-C, Guldberg RE, Gerstenfeld LC, Haase VH, Johnson RS, Schipani E, Clemens TL (2007) The hypoxia-inducible factor pathway couples angiogenesis to osteogenesis during skeletal development. J Clin Invest 2007; 117(6):1616-26.
69. Bouxsein ML, Szulc P, Munoz F, Thrall E, Sornay-Rendu E, Delmas PD. Contribution of trochanteric soft tissues to fall force estimates, the factor of risk, and prediction of hip fracture. J Bone Min Res 2007: 22(6): 25-31.
68. Yang D, Singh R, Divieti P, Guo J, Bouxsein ML, Bringhurst FR. Contributions of parathyroid hormone (PTH)/PTH-related peptide receptor signaling pathways to the anabolic effect of PTH on bone. Bone 2007; 40 (6): 1453-61.
67. Liu X, Bruxvoort KJ, Zylstra CR, Liu J, Cichowski R, Faugere M-C, Bouxsein ML, Wan C, Williams BO, Clemens TL. Lifelong accumulation of bone in mice lacking Pten in osteoblasts. Proc Natl Acad Sci 2007; 104 (7): 2259-64.
66. Notini A, McManus JF, Moore A, Bouxsein M, Jimenez M, Chiu WM, Glatt V, Kream BE, Handelsman DJ, Morris H, Zajac JD, Davey RA. Osteoblast deletion of exon 3 of the androgen receptor gene results in trabecular bone loss in adult male mice. J Bone Min Res 2007; 22 (3): 347-56.
65. Hsu YH, Xu X, Terwedow HA, Niu T, Hung X, Wu D, Wang L, Brain JD, Bouxsein ML, Cummings SR, Rosen CJ. A large-scale genome-wide linkage analysis for loci linked to bone mineral density at different skeletal sites in extreme selected sibships. J Bone Min Res 2007; 22 (2): 184-194.
64. Zalloua PA, Hsu YH, Terwedo H, Zang T, Wu D, Tang G, Li Z, Hong X, Azar ST, Wang B, Bouxsein ML, Brain J, Cummings SR, Rosen CJ, Xu X. Impact of seafood and fruit consumption on bone mineral density. Maturitas 2007; 56 (1): 1-11.
63. Bouxsein ML, Riggs BL, Melton LJ III, Muller JA, Atkinson EJ, Oberg A, Robb RA, Camp JJ, Rouleau PA, McCollough CH, Khosla S. Biomechanical assessment of the age- and sex-related differences vertebral fragility: A population-based study using QCT. J Bone Min Res 2006; 21 (9): 1475-82.
62. Viguet-Carrin S, Roux JP, Arlot ME, Merabet Z, Leeming J, Byrjalsen I, Delmas PD, Bouxsein ML. Contribution of the advanced glycation endproduct pentosidine and maturation of the collagen to compressive biomechanical properties of human lumbar vertebrae. Bone 2006; 39 (5): 1073-9.
61. Pierroz DP, Bouxsein ML, Rizzoli R, Ferrari SL. Combined treatment with a beta-blocker and intermittent PTH improves bone mass and microarchitecture in ovariectomized mice. Bone 2006; 39 (2): 260-7.
60. Yakar S, Bouxsein ML, Canalis E, Sun H, Glatt V, Gundberg C, Cohen P, Hwang D, Boisclair Y, Leroith D, Rosen CJ. The ternary IGF complex influences postnatal bone acquisition and the skeletal response to intermittent parathyroid hormone. Journal of Endocrinol 2006; 189 (2): 289-99.
59. Garnero P, Borel O, Gineyts E, Duboeuf F, Solberg H, Bouxsein ML, Christiansen C, Delmas PD. Extracellular post-translational modifications of collagen are major determinants of biomechanical properties of fetal bovine cortical bone. Bone 2006; 38: 300-9.
58. Betz OB, Betz VM, Nazarian A, Pilapil CG, Vrahas MS, Bouxsein ML, Gerstenfeld LC, Einhorn TA, Evans, CH. Direct percutaneous gene delivery to enhance healing of segmental bone defects. J Bone Joint Surg (Am) 2006; 88:355-65.
57. Hsu YH, Venners SA, Terwedow HA, Feng Y, Niu T, Li Z, Laird N, Brain JD, Cummings SR, Bouxsein ML, Rosen CJ, Xu X. Relationship of body composition, fat mass and serum lipids to osteoporotic fractures and bone mineral density in Chinese men and women. Am J Clin Nutr 2006; 83: 146-54.
56. Riggs BL, Melton LJ, Robb RA, Camp JJ, Atkinson EJ, Oberg A, Rouleau PA, McCollough CH, Khosla S, Bouxsein ML. Population based analysis of the relationship of whole bone strength indices and fall-related loads to age- and sex-specific patterns of hip and wrist fractures. J Bone Min Res 2006; 21:315-23.
55. Seeherman H, Li R, Bouxsein M, Kim H, Li XJ, Smith-Adaline E, Aiolova M, Wozney JM. rhBMP-2/calcium phosphate matrix accelerates osteotomy-site healing in a non-human primate model at multiple treatment times and concentrations. J Bone Jt Surg (Am) 2006; 88: 144-160.
54. Feng Y, Hsu YH, Terwedow H, Chen C, Xu X, Niu T, Zang T, Wu D, Tang G, Li Z, Hong X, Wang B, Brain JD, Cummings SR, Rosen C, Bouxsein ML, Xu X. Familial aggregation of bone mineral density and bone mineral content in a Chinese population. Osteop Int 2005: 16 (12): 1917-23.
53. Boutroy S, Bouxsein ML, Munoz F, Delmas PD. In vivo assessment of trabecular microarchitecture by high-resolution peripheral quantitative computed tomography. J Clin Endocrin & Metab 2005; 90 (12): 6508-15.
52. Holmen SL, Zylstra CR, Mukherjee A, Sigler RE, Faugere MC, Bouxsein ML, Deng L, Clemens TL, Williams BO. Essential role of beta-catenin in post-natal bone acquisition. J Biol Chem 2005; 280 (22): 21162-8.
51. Bouxsein ML, Myers KS, Shultz KL, Donahue LR, Rosen CJ, Beamer WJ. Ovariectomy-induced bone loss varies among inbred strains of mice. J Bone Min Res 2005; 20 (7): 1085-92.
50. Knopp E, Troiano N, Bouxsein M, Sun BH, Lostritto K, Gundberg C, Dziura J, Insogna K. The effect of aging on the skeletal response to intermittent treatment with parathyroid hormone. Endocrinology 2005; 146: 1983-1990.
49. Ferrari SL, Pierroz DD, Glatt V, Goddard DS, Bianchi EN, Lin FT, Manen D, Bouxsein ML. Bone response to intermittent parathyroid hormone is altered in mice null for ß-arrestin2. Endocrinology 2005; 146:1854-1862.
48. Bouxsein ML, Pierroz D, Glatt V, Goddard DS, Cavat F, Rizzoli R, Ferrari SL. Beta-arrestin2 regulates the differential response of cortical and trabecular bone to intermittent PTH in female mice. J Bone Min Res, 2005; 20:635-43.
47. Rosen CJ, Ackert-Bicknell C, Beamer WG, Nelson T, Adamo M, Cohen P, Bouxsein ML, Horowitz MC. Allelic differences in quantitative trait locus affecting insulin-like growth factor-I impact skeletal acquisition and body composition. Pediatr Nephrol, 2005; 20:255-260.

Publications 2000 – 2004

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46. Rosen CJ, Ackert-Bicknell CL, Adamo ML, Shultz KL, Rubin J, Donahue LR, Horton LG, Delahunty KM, Beamer WG, Sipos J, Clemmons D, Nelson T, Bouxsein ML, Horowitz M. Congenic mice with low serum IGF-1 have increased body fat, reduce bone mineral density, and an altered osteoblast differentiation program. Bone, 2004; 35 (5): 1046-58.
45. Riggs BL, Melton LJ, Robb RA, Camp JJ, Atkinson EJ, Peterson JM, Rouleau PA, McCollough CH, Bouxsein ML, Khosla S. Population-based study of age and sex differences in bone volumetric density, size, geometry and structure at different skeletal sites. J Bone Min Res 2004; 19:1945-54.
44. Holmen SL, Giambernardi TA, Zylstra CR, Buckner-Berghaus BD, Resau JH, Hess JF, Glatt V, Bouxsein ML, Ai M, Warman ML, Williams BO. Decreased bone density and limb deformities in mice carrying mutations in both Lrp5 and Lrp6. J Bone Min Res 2004; 19: 2033-40.
43. Bouxsein ML, Kaufman J, Tosi L, Cummings S, Lane J, Johnell O. Recommendations for care of the osteoporotic fracture patient to reduce the risk of future fracture. J Am Acad Orthop Surg 2004; 12 (6): 385-95.
42. Seeherman H, Bouxsein M, Kim H, Li R, Li XJ, Aiolova M, Wozney JM. Recombinant human bone morphogenetic protein-2 delivered in an injectable calcium phosphate paste accelerates osteotomy healing in a nonhuman primate model. J Bone Jt Surg 2004 ; 86-A: 1961-72.
41. Bertone AL, Pittman DD, Bouxsein ML, Li J, Clancy B, Seeherman HJ. Adenoviral-mediated transfer of human BMP-6 gene accelerates healing in a rabbit ulnar osteotomy model. J Orthop Res 2004; 22: 1261-70.
40. Johnston JD, Small CF, Bouxsein ML, Pichora DR. Mechanical properties of the scapholunate ligament correlate with bone mineral density measurements of the hand. J Orthop Res 2004; 22 (4): 867-871.
39. Bouxsein ML, Uchiyama T, Rosen CJ, Shultz KL, Donahue LR, Turner CH, Sen S, Churchill G, Müller RA, Beamer, WG. Mapping quantitative trait loci for vertebral trabecular bone volume fraction and microarchitecture in mice. J Bone Min Res 2004; 19: 587-599.
38. Kacena M, Shivdasani RA, Wilson K, Yougen X, Troiano N, Nazarian A, Gundberg C, Bouxsein ML, Lorenzo JA, Horowitz MC. Unsuspected megakaryocyte-osteoblast interaction revealed through increased bone formation in mice deficient in transcription factors GATA-1 and NF-E2. J Bone Min Res 2004; 19:652-660.
37. Yakar S, Setser J, Zhao H, Atannard B, Haluzik M, Glatt V, Bouxsein M, Kopchick J, LeRoith D. Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1 deficient mice. J Clin Invest 2004; 113: 96-105.
36. Tingart MJ, Bouxsein ML, Zurakowski DE, Warner JJP, Apreleva M. Three-dimensional distribution of bone density in the proximal humerus. Calcif Tissue Int 2003; 73 (6): 531-6.
35. Li RH, Bouxsein ML, Blake CA, D’August D, Li XJ, Wozney JM, Kim H, Seeherman, HJ. rhBMP-2 injected in a calcium phosphate paste (a-BSM) accelerates healing in the rabbit ulnar osteotomy model. J Orthop Res 2003; 21 (6): 997-1004.
34. Turner CH, Sun Q, Schriefer J, Pitner N, Price R, Bouxsein ML, Rosen CJ, Donahue LR, Shultz KL, Beamer WG. Congenic mice reveal gender-specific genetic regulation of femoral structure and strength. Calcif Tissue Int 2003; 73 (3): 297-303.
33. Black DM, Greenspan SL, Ensrud KE, Palermo L, McGowan JA, Lang TF, Garnero P, Bouxsein ML, Bilezikian JP, Rosen CJ. The effects of PTH and alendronate alone or in combination in post-menopausal osteoporosis. N Engl J Med 2003; 349 (13): 1207-1215.
32. Einhorn TA, Majeska RJ, Mohaideen A, Kagel EM, Bouxsein ML, Turek TJ, Wozney JM. A single percutaneous injection of recombinant human bone morphogenetic protein-2 accelerates fracture repair. J Bone Jt Surg 2003; 85-A: 1425-35.
31. Bonner FJ, Sinaki M, Grabois M, Shipp KM, Lane JM, Lindsay R, Gold DT, Cosman F, Bouxsein ML, Weinstein JN, Gallagher RM, Melton LJ, Salcido RS, Gordon SL. Health professional’s guide to rehabilitation of the patient with osteoporosis. Osteoporosis Int 2003; 14 (suppl 2): S1-S22.
30. Babij P, Zhao W, Small C, Reddy PS, Yaworsky PJ, Bouxsein M, Bodine PVN, Robinson JA, Moran RA, Kharode Y, Bex F. High bone mass in transgenic mice expressing a mutant human low-density lipoprotein receptor related protein 5 (LRP5). J Bone Min Res 2003; 18: 960-974.
29. Muller ME, Webber CE, Bouxsein ML. Predicting the failure load of the distal radius. Osteoporosis Int 2003; 14: 345-52.
28. Zhang M, Xuan S, Bouxsein ML, von Stechow D, Faugere MC, Malluche H, Zhao G, Rosen CJ, Efstratiadis A, Clemens TL. Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF-1 signaling in bone matrix mineralization. J Biol Chem 2002; 277 (46): 44005-12.
27. Shultz K, Donahue LR, Bouxsein ML, Baylink D, Rosen CJ, Beamer WG. Genetic decomposition of quantitative trait loci for high and low volumetric bone mineral density using congenic strains of mice. J Bone Min Res 2003; 18 (2) 175-85.
26. Li G, Bouxsein ML, Luppen C, Li XJ, Wood M, Seeherman HJ, Wozney JM, Simpson H. Bone consolidation in enhanced by rhBMP-2 in a rabbit model of distraction osteogenesis. J Orthop Res 2002; 20: 779-788.
25. Nicholson PHF and Bouxsein ML. Bone marrow influences quantitative ultrasound measurements in human cancellous bone. Ultrasound in Medicine and Biology 2002; 28: 369-75.
24. Nicholson PHF, Bouxsein ML. Effect of temperature on ultrasonic properties of the calcaneus in situ. Osteoporosis Int 2002; 13 (11): 888-892.
23. Bouxsein ML, Palermo L, Yeung C, Black DM. Digital x-ray radiogrammetry predicts hip, wrist and vertebral fracture risk in elderly women: A prospective analysis from the Study of Osteoporotic Fractures. Osteoporosis Int 2002; 13: 358-365.
22. Bouxsein ML, Rosen CJ, Ackert CA, Shultz KL, Donahue LR, Adamo M, Powell DR. Turner CH, Müller RA, Beamer WG. Testing the relationship of IGF-1 to bone mineral density, skeletal morphology and fragility in vivo: Generation of a new congenic mouse strain. J Bone Min Res 2002; 17: 570-579.
21. Luppen CA, Blake CA, Ammirati KM, Stevens ML, Li XJ, Seeherman HJ, Wozney JM, Bouxsein ML. rhBMP-2 enhances osteotomy healing in glucocorticoid treated rabbits. J Bone Min Res 2002; 17: 301-310.
20. Bouxsein ML, Turek TJ, Blake CA, Stevens ML, Li XJ, Seeherman HJ, Wozney JM. Recombinant human bone morphogenetic protein-2 accelerates osteotomy healing in rabbit model. J Bone Jt Surgery 2001; 83-A: 1219-1230.
19. Turner CHT, Hsieh Y-F, Müller R, Bouxsein ML, Rosen CJ, McCrann ME, Donahue LR, Beamer WG. Variation in bone biomechanical properties, microstructure and density in BxH recombinant inbred mice. J Bone Min Res. 2001; 16: 206-213.
18. Nicholson PHF, Bouxsein ML. Quantitative ultrasound does not reflect mechanically induced damage in cancellous bone. J Bone Min Res 2000; 15:2467-2472.
17. McClean RR, Hannan MT, Epstein BE, Bouxsein ML, Cupples LA, Murabito J, Kiel DP. Elderly cohort study subjects unable to return for follow-up have lower bone mass than those who can return. Am J Epidemiology 2000; 151: 689-692.
16. Nicholson PHF, Strelitzki R, Cleveland RO, Bouxsein ML. Scattering of ultrasound in cancellous bone: fundamental concepts and predictions from a theoretical model. J Biomechanics 2000; 33 (4): 503-506.
15. Turner CHT, Hsieh Y-F, Müller R, Bouxsein ML, Baylink DJ, Rosen CJ, Grynpas MD, Donahue LR, Beamer WG. Genetic regulation of cortical and trabecular bone strength and microstructure in inbred strains of mice. J Bone Min Res 2000; 15: 1126-1131.
14. Bouxsein ML, Parker RA, Greenspan SL. Forearm bone mineral density cannot be used to predict the response to alendronate therapy. Osteoporosis Int 2000; 10: 505-509.

 

 

Publications 1995 – 1999

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13. Bouxsein ML, Coan BS, Lee SC. Prediction of femoral strength by bone mineral density and quantitative ultrasound measurements of the heel and tibia. Bone 1999; 25: 49-54.
12. Oden ZM, Selvitelli DM, Bouxsein ML. Effect of local density changes on the failure load of the proximal femur. J Orthop Res 1999; 16:661-667.
11. Michaeli DA, Mirshahi A, Singer F, Rapa F, Plass D, Bouxsein M. A new x-ray based osteoporosis screening tool provides accurate and precise assessment of phalanx bone mineral content. J Clin Densitometry 1999; 2:23-30.
10. Bouxsein ML, Michaeli DA, Plass DB, Schick DA, Melton ME. Precision and accuracy of computed digital absorptiometry (CDA) for assessment of bone density of the hand. Osteoporosis Int 1997; 7: 444-449.
9. Greenspan SL, Bouxsein ML, Melton ME, Kolodny AH, Clair JH, DeLuca PT, Stek M, Faulkner KG, Orwoll ES. Precision and discriminatory ability of calcaneal bone assessment techniques. J Bone Min Res 1997; 12: 1303-1313.
8. Lee SC, Coan BS, Bouxsein ML. Longitudinal ultrasound velocity of the tibia predicts the material properties of tibial cortical bone. Bone 1996; 21: 119-125.
7. Bouxsein ML, Radloff SE. Quantitative ultrasound of the calcaneus reflects the mechanical properties of calcaneal trabecular bone. J Bone Min Res 1996; 12: 839-846.
6. Moro M, Hecker AT, Bouxsein ML, Myers ER. Failure load of thoracic vertebrae correlates with lumbar bone mineral density measure by DXA. Calcif Tissue Int 1995; 56: 206-209.
5. Bouxsein ML, Courtney AC, Hayes WC. Ultrasound and densitometry of the calcaneus correlate with the failure loads of cadaveric femurs. Calcif Tissue Int 1995; 56: 99-103.

 

 

Publications 1990 – 1994

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4. Bouxsein ML, Myburgh KH, van der Meulen MCH, Lindenberger E, Marcus R. Age-related differences in cross-sectional geometry of the forearm bones in healthy women. Calcif Tissue Int 1994; 54:113-118.
3. Carter DR, Bouxsein ML, Marcus R. New interpretations of projected bone densitometry data. J Bone Min Res 1992; 7: 137-145.
2. Snow-Harter C, Bouxsein ML, Lewis BT, Carter DR, Marcus R. Effects of resistance and endurance exercise on bone mineral status of young women: A randomized exercise intervention trial. J Bone Min Res 1992; 7: 761-769.
1. Snow-Harter C, Bouxsein M, Lewis B, Charette S, Weinstein P, Marcus R. Muscle strength as a predictor of bone mineral density in young women. J Bone Min Res 1990; 5: 589-595.