Principal Investigator

Dr. Mary Bouxsein

Mary L Bouxsein, PhD
Director, Center for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center
Associate Professor, Department of Orthopedic Surgery, Harvard Medical School
Associate Biologist, Endocrine Division, Massachusetts General Hospital
Adjunct Assistant Professor, Department of Mechanical Engineering, Boston University
Faculty Member, Bioastronautics Program, Harvard-MIT Division of Health Sciences and Technology

330 Brookline Ave, RN 115
Boston, MA 02215
Phone: 617-667-2940, fax: 617-667-7175
Email: mbouxsei@bidmc.harvard.edu

Dr. Bouxsein received her BS degree in General Engineering from the University of Illinois at Urbana-Champaign, and PhD in Mechanical Engineering from Stanford University, studying the effects of exercise on the skeleton with Dennis Carter, PhD and Robert Marcus, MD. She then completed a post-doctoral fellowship at the Orthopedic Biomechanics Laboratory at Beth Israel Deaconess Medical Center and Harvard Medical School under the mentorship of Wilson C. Hayes, PhD. She currently holds joint appointments as an Assistant Professor of Orthopedic Surgery at Harvard Medical School, adjunct Assistant Professor of Mechanical Engineering at Boston University, and is also a faculty member in the MIT-Bioastronautics Program. Her research focuses on understanding skeletal fragility from a biomechanics viewpoint, and includes studies using animal models and human cadaveric tissue, as well as clinical investigations. She also has a strong interest in the use of novel non-invasive imaging techniques to predict fracture risk and monitor response to osteoporosis therapies. Dr. Bouxsein serves on the committee of scientific advisors for the International Osteoporosis Foundation and is a board member of the International Bone and Mineral Society. Dr. Bouxsein has published over 145 peer-reviewed articles and 25 book chapters and invited reviews.

See Dr. Bouxsein’s CV.

Faculty

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Dennis E. Anderson, PhD
Assistant Professor of Orthopedic Surgery, Harvard Medical School
330 Brookline Avenue, RN 115
Boston, MA 02215
Phone: 617-667-5380, Fax: 617-667-7175
Email: danders7@bidmc.harvard.edu

Dr. Anderson received his PhD in Engineering Mechanics from Virginia Tech in 2010, studying musculoskeletal biomechanics with a focus on aging and gait under the direction of Michael Madigan, PhD. He then joined the lab as a postdoctoral fellow to work in the Biomechanics of Vertebral Fracture project, using qCT scans and musculoskeletal modeling to examine the risk of vertebral fractures in older adults. In 2015, Dr. Anderson was promoted to Assistant Professor of Orthopedic Surgery, and currently his research seeks to understand thoracolumbar biomechanics in several inter-related areas: examining how in vivo measurements of trunk musculature from CT scans are associated with age, sex and physical function; in vitro mechanical testing of cadaveric specimens to characterize the mechanical properties of costal cartilage and understand how the rib cage and rib cage stiffness affect loading of the thoracic vertebrae; development and validation of improved musculoskeletal models of the thoracolumbar spine; and examination of biomechanical factors that affect vertebral loading.

See Dr. Anderson’s CV.

Postdoctoral Fellows

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Hossein Mokhtarzadeh, PhD, GCALL
Research Fellow
330 Brookline Avenue, RN 119
Boston, MA 02215
Email: hmokhtar@bidmc.harvard.edu

Dr. Hossein Mokhtarzadeh received his PhD in Mechanical Engineering from The University of Melbourne in 2014, investigating biomechanics of anterior cruciate ligament (ACL) injury mechanism during high impact load using experimental and computational models with Prof. Peter Lee and A/Prof. Denny Oetomo. Hossein’s doctoral research won a national award of Fresh Science as one of the 12 Early Career Researchers in Australia in 2013 (“Fresh Science is a national event which brings together scientists, the media and the public”). The research findings made using OpenSim during his PhD reached millions of individuals through major media outlets. During his postdoctoral fellowship at the University of Melbourne, he was awarded outstanding researcher award from Stanford University. In 2015, Hossein joined Bouxsein Lab as a Research Fellow to study biomechanics of Vertebral Fracture in older adults using a combination of in-vivo and in-silico models.Cool stuff happening, so stay tuned!

See Dr. Mokhtarzadeh’s CV.

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Seyed Javad Mousavi, PT, PhD
Research Fellow
330 Brookline Avenue, RN 122
Boston, MA 02215
Email: smousavi@bidmc.harvard.edu

Dr. Mousavi received his PhD in Physical Therapy from Tehran University of Medical Sciences (TUMS) in 2008, studying trunk neuromuscular performance during multidirectional tracking tasks with Prof. Mohamad Parnianpour, PhD. Upon graduation he also received “the national award for the distinguished student researcher” for his works on development and implementation of patient-reported outcome measures and evidence-based practice for musculoskeletal disorders. After working as assistant professor of physical therapy at TUMS for three years, in 2012 he was awarded “University of Sydney International Postdoctoral Research Fellowship” to work on trunk control during simple and complex motion tracking tasks. In 2016, he joined the Bouxsein lab as a research fellow to work with Dr. Dennis Anderson on thoracic motion, osteoporotic vertebral fracture and trunk neuromuscular performance with a clinical point of view.

See Dr. Mousavi’s CV.

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Fjola Johannesdottir, PhD
Research Fellow
330 Brookline Avenue, RN 119
Boston, MA 02215
Email: fjohanne@bidmc.harvard.edu

Dr. Johannesdottir received her PhD in Mechanical Engineering from University of Iceland in 2012, where she used 3D musculoskeletal imaging to study the determinants of osteoporotic fragility among elderly people, especially hip fractures, and to assess age related changes by examining bone structure and shape. During her postdoc at University of Cambridge (UK), she expanded her imaging skills by using novel parametric mapping of femoral bone in patients with and without hip fractures and by using MRI images to assess bone health among Gaucher patients. She then joined the Bouxsein lab in 2016 to expand her biomechanics background and gain experience in biomechanical testing. Currently, her research seeks to understand how in-vivo CT measurements of trunk muscles vary with age and sex among adults; and whether deficits in trunk muscle density are associated with increased risk of incident vertebral fracture. She is also investigating the biomechanical behavior of the bone tissue from patients with longstanding type 1 diabetes mellitus to better understand mechanisms underlying skeletal fragility with this condition.

Frank Ko, PhD
Research Fellow
330 Brookline Avenue, RN 122
Boston, MA 02215
Email: fko@bidmc.harvard.edu

Dr. Ko received his BS degree in Bioengineering from Rice University and PhD in Mechanical Engineering from Cornell University under the mentorship of Marjolein van der Meulen, PhD.  He then pursued a post-doctoral fellowship in molecular biology at the Endocrine Unit at Massachusetts General Hospital under the mentorship of Marie Demay, MD and subsequently with Mary Bouxsein, PhD at the Center for Advanced Orthopaedic Studies at Beth Israel Deaconess Medical Center.  Dr. Ko is interested in defining the molecular basis of musculoskeletal changes from mechanical loading/unloading and nutrition using preclinical models and in vitro systems.  He is currently investigating how partial weight bearing alters muscle and bone and determining the effects of caloric restriction on mTOR signaling in bone.

Graduate Students

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Katelyn Burkhart
Ph.D. Candidate – Medical Engineering and Medical Physics
Harvard-MIT Division of Health Sciences and Technology
Bioastronautics Training Program
Email: katelynb@mit.edu

Katelyn received her bachelor’s and master’s degrees from the University of Connecticut. She is currently a PhD student in the Harvard-MIT Division of Health Sciences and Technology (HST) Bioastronautics program, and joined the Bouxsein lab group in 2014. Her research involves developing a subject-specific musculoskeletal model of the thoracolumbar spine using OpenSim software. This musculoskeletal model can be used to predict in vivo spinal loading and help identify high risk activities that might place someone at risk for vertebral fracture. Currently, she is investigating the effect of spaceflight on the risk of vertebral fracture for astronauts.

Research Associates

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Daniel Brooks
Laboratory Manager, Bouxsein Lab and Center for Advanced Orthopaedic Studies

Email: djbrooks@bidmc.harvard.edu

Daniel Brooks joined the Bouxsein Lab as a Research Associate in 2012. Prior to coming to BIDMC, he worked for five years at Cornell University managing two research labs. He received a Bachelor’s of Science in Biological Engineering from The University of Maine in 2004 and a Master’s of Science in Biomedical Engineering from the Joint Program of North Carolina State University and UNC-Chapel Hill in 2007. His previous research has looked at cementless hip implant stability, the effect of osteoporosis drugs on the mechanical properties of bone, and the growth of tumors in the bone microenvironment. Currently, Daniel helps with mechanical testing, µCT imaging, in vivo studies, and numerous other aspects of the projects in the Bouxsein lab.

Research Assistants

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Brett Allaire
Email: ballaire@bidmc.harvard.edu

Brett Allaire graduated with a Bachelor of Science degree in Biomedical Engineering from Boston University in 2009. As an undergrad, Brett did work in the BU Biomicroscopy Lab. He joined the Bouxsein lab in March 2011 and is part of the Biomechanics of Vertebral Fracture team performing image analysis of QCT scans. His research interests include imaging techniques, image processing, and biomechanics.

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Julia Moulton
Email: jmoulton@bidmc.harvard.edu

Julia Moulton graduated from Northeastern University with a B.S. in Mechanical Engineering and a minor in Biomechanics in May 2015. She conducted co-ops with ABIOMED, Pioneer Surgical Technology, and Arthrex. From these jobs, she has industrial experience in cardiovascular biomechanics, designing hydroxyapatite based biologic devices for the spine, and testing medical devices used in sports medicine (sutures, suture anchors, total knee/hip replacement kits, buttons, etc.). In the past she has worked on projects that (1) researched possible mechanisms to diminish the chances of bone fracture in individuals with Osteogenesis Imperfecta and (2) tried to deepen the understanding of how loading at different intensities can contribute to osteoarthritis. Julia joined the Bouxsein lab in March 2016. Her research interests are broad, but she generally has an affinity for anything having to do with joints, bone or cartilage.

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Rebecca Tromp
Email: rtromp@bidmc.harvard.edu

Becky received her bachelor’s degree in Biomedical Engineering from Case Western Reserve University in 2012 and her master’s degree in Biomedical Engineering from the University of Kentucky in 2015. Her previous research focused on the effects of military body armor on the trunk’s neuromuscular and mechanical behaviors. Becky joined the lab in March 2016 and is working with Dr. Dennis Anderson on using motion analysis to determine the effects of aging and hyperkyphosis on thoracic spine motion and loading.